TY - JOUR
T1 - Cardiac Troponin I Detection using Gold/Cerium-Oxide Nanoparticles assisted Hetro-Core Fiber Structure
AU - Wang, Yu
AU - Singh, Ragini
AU - Li, Muyang
AU - Min, Rui
AU - Wu, Qiang
AU - Kaushik, Brajesh Kumar
AU - Jha, Rajan
AU - Zhang, Bingyuan
AU - Kumar, Santosh
N1 - Funding information: This work was supported in part by the Double-Hundred Talent Plan of Shandong Province; in part by the Special Construction Project Fund for Shandong Province Taishan Mountain Scholars; in part by the Liaocheng University under Grant 318051901, Grant 31805180301, and Grant 31805180326; in part by the Natural Science Foundation of Shandong Province under Grant ZR2020QC061; in part by the National Natural Science Foundation of China under Grant 62003046; and in part by the Guangdong Basic and Applied Basic Research Foundation under Grant 2021A1515011997.
PY - 2023/4/3
Y1 - 2023/4/3
N2 - The article describes the development of a hetro-core optical fiber sensor structure based on localized surface plasmon resonance (LSPR) for the detection of cardiac troponin I (cTnI) solution. This was accomplished by fabricating a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure. Then, fiber structure is immobilized with gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2-NPs) to improve its sensing capabilities. An UV-Vis spectrophotometer and a high-resolution transmission electron microscope (HR-TEM) are used to determine the morphology of synthesized nanoparticles. Scanning electron microscopy (SEM) is used to examine the state of immobilized NPs on the surface of sensing region. The developed sensor probe has a linear range of 0 to 1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a limit of detection (LoD) of 108.15 ng/mL. In real time, the proposed sensor will be used in a practice to detect acute myocardial infarction (AMI).
AB - The article describes the development of a hetro-core optical fiber sensor structure based on localized surface plasmon resonance (LSPR) for the detection of cardiac troponin I (cTnI) solution. This was accomplished by fabricating a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure. Then, fiber structure is immobilized with gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2-NPs) to improve its sensing capabilities. An UV-Vis spectrophotometer and a high-resolution transmission electron microscope (HR-TEM) are used to determine the morphology of synthesized nanoparticles. Scanning electron microscopy (SEM) is used to examine the state of immobilized NPs on the surface of sensing region. The developed sensor probe has a linear range of 0 to 1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a limit of detection (LoD) of 108.15 ng/mL. In real time, the proposed sensor will be used in a practice to detect acute myocardial infarction (AMI).
KW - Biosensors
KW - Nanoparticles
KW - Optical fiber biosensor
KW - Optical fiber sensors
KW - Optical fibers
KW - Probes
KW - Scanning electron microscopy
KW - Sensitivity
KW - cardiac troponin I
KW - cerium oxide nanoparticles
KW - gold nanoparticles
KW - hetro-core fiber structure
KW - localized surface plasmon resonance
UR - https://www.scopus.com/pages/publications/85135225519
U2 - 10.1109/tnb.2022.3192491
DO - 10.1109/tnb.2022.3192491
M3 - Article
SN - 1536-1241
VL - 22
SP - 375
EP - 382
JO - IEEE Transactions on Nanobioscience
JF - IEEE Transactions on Nanobioscience
IS - 2
ER -