Cardiac Troponin I Detection using Gold/Cerium-Oxide Nanoparticles assisted Hetro-Core Fiber Structure

Yu Wang; Ragini Singh; Muyang Li; Rui Min; Qiang Wu; Brajesh Kumar Kaushik; Rajan Jha; Bingyuan Zhang; Santosh Kumar

doi:10.1109/tnb.2022.3192491

Cardiac Troponin I Detection using Gold/Cerium-Oxide Nanoparticles assisted Hetro-Core Fiber Structure

Yu Wang, Ragini Singh^*, Muyang Li, Rui Min, Qiang Wu, Brajesh Kumar Kaushik, Rajan Jha, Bingyuan Zhang^*, Santosh Kumar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The article describes the development of a hetro-core optical fiber sensor structure based on localized surface plasmon resonance (LSPR) for the detection of cardiac troponin I (cTnI) solution. This was accomplished by fabricating a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure. Then, fiber structure is immobilized with gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2-NPs) to improve its sensing capabilities. An UV-Vis spectrophotometer and a high-resolution transmission electron microscope (HR-TEM) are used to determine the morphology of synthesized nanoparticles. Scanning electron microscopy (SEM) is used to examine the state of immobilized NPs on the surface of sensing region. The developed sensor probe has a linear range of 0 to 1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a limit of detection (LoD) of 108.15 ng/mL. In real time, the proposed sensor will be used in a practice to detect acute myocardial infarction (AMI).

Original language	English
Pages (from-to)	375-382
Number of pages	8
Journal	IEEE Transactions on Nanobioscience
Volume	22
Issue number	2
Early online date	19 Jul 2022
DOIs	https://doi.org/10.1109/tnb.2022.3192491
Publication status	Published - 3 Apr 2023

Keywords

Biosensors
Nanoparticles
Optical fiber biosensor
Optical fiber sensors
Optical fibers
Probes
Scanning electron microscopy
Sensitivity
cardiac troponin I
cerium oxide nanoparticles
gold nanoparticles
hetro-core fiber structure
localized surface plasmon resonance

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10.1109/tnb.2022.3192491

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@article{4617933543a643a9bf1663859790fa7d,

title = "Cardiac Troponin I Detection using Gold/Cerium-Oxide Nanoparticles assisted Hetro-Core Fiber Structure",

abstract = "The article describes the development of a hetro-core optical fiber sensor structure based on localized surface plasmon resonance (LSPR) for the detection of cardiac troponin I (cTnI) solution. This was accomplished by fabricating a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure. Then, fiber structure is immobilized with gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2-NPs) to improve its sensing capabilities. An UV-Vis spectrophotometer and a high-resolution transmission electron microscope (HR-TEM) are used to determine the morphology of synthesized nanoparticles. Scanning electron microscopy (SEM) is used to examine the state of immobilized NPs on the surface of sensing region. The developed sensor probe has a linear range of 0 to 1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a limit of detection (LoD) of 108.15 ng/mL. In real time, the proposed sensor will be used in a practice to detect acute myocardial infarction (AMI). ",

keywords = "Biosensors, Nanoparticles, Optical fiber biosensor, Optical fiber sensors, Optical fibers, Probes, Scanning electron microscopy, Sensitivity, cardiac troponin I, cerium oxide nanoparticles, gold nanoparticles, hetro-core fiber structure, localized surface plasmon resonance",

author = "Yu Wang and Ragini Singh and Muyang Li and Rui Min and Qiang Wu and Kaushik, \{Brajesh Kumar\} and Rajan Jha and Bingyuan Zhang and Santosh Kumar",

note = "Funding information: This work was supported in part by the Double-Hundred Talent Plan of Shandong Province; in part by the Special Construction Project Fund for Shandong Province Taishan Mountain Scholars; in part by the Liaocheng University under Grant 318051901, Grant 31805180301, and Grant 31805180326; in part by the Natural Science Foundation of Shandong Province under Grant ZR2020QC061; in part by the National Natural Science Foundation of China under Grant 62003046; and in part by the Guangdong Basic and Applied Basic Research Foundation under Grant 2021A1515011997.",

year = "2023",

month = apr,

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doi = "10.1109/tnb.2022.3192491",

language = "English",

volume = "22",

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journal = "IEEE Transactions on Nanobioscience",

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publisher = "IEEE",

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TY - JOUR

T1 - Cardiac Troponin I Detection using Gold/Cerium-Oxide Nanoparticles assisted Hetro-Core Fiber Structure

AU - Wang, Yu

AU - Singh, Ragini

AU - Li, Muyang

AU - Min, Rui

AU - Wu, Qiang

AU - Kaushik, Brajesh Kumar

AU - Jha, Rajan

AU - Zhang, Bingyuan

AU - Kumar, Santosh

N1 - Funding information: This work was supported in part by the Double-Hundred Talent Plan of Shandong Province; in part by the Special Construction Project Fund for Shandong Province Taishan Mountain Scholars; in part by the Liaocheng University under Grant 318051901, Grant 31805180301, and Grant 31805180326; in part by the Natural Science Foundation of Shandong Province under Grant ZR2020QC061; in part by the National Natural Science Foundation of China under Grant 62003046; and in part by the Guangdong Basic and Applied Basic Research Foundation under Grant 2021A1515011997.

PY - 2023/4/3

Y1 - 2023/4/3

N2 - The article describes the development of a hetro-core optical fiber sensor structure based on localized surface plasmon resonance (LSPR) for the detection of cardiac troponin I (cTnI) solution. This was accomplished by fabricating a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure. Then, fiber structure is immobilized with gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2-NPs) to improve its sensing capabilities. An UV-Vis spectrophotometer and a high-resolution transmission electron microscope (HR-TEM) are used to determine the morphology of synthesized nanoparticles. Scanning electron microscopy (SEM) is used to examine the state of immobilized NPs on the surface of sensing region. The developed sensor probe has a linear range of 0 to 1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a limit of detection (LoD) of 108.15 ng/mL. In real time, the proposed sensor will be used in a practice to detect acute myocardial infarction (AMI).

AB - The article describes the development of a hetro-core optical fiber sensor structure based on localized surface plasmon resonance (LSPR) for the detection of cardiac troponin I (cTnI) solution. This was accomplished by fabricating a single-mode fiber - multimode fiber - single-mode fiber (SMS) structure. Then, fiber structure is immobilized with gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2-NPs) to improve its sensing capabilities. An UV-Vis spectrophotometer and a high-resolution transmission electron microscope (HR-TEM) are used to determine the morphology of synthesized nanoparticles. Scanning electron microscopy (SEM) is used to examine the state of immobilized NPs on the surface of sensing region. The developed sensor probe has a linear range of 0 to 1000 ng/mL cTnI, a sensitivity of 3 pm/(ng/mL), and a limit of detection (LoD) of 108.15 ng/mL. In real time, the proposed sensor will be used in a practice to detect acute myocardial infarction (AMI).

KW - Biosensors

KW - Nanoparticles

KW - Optical fiber biosensor

KW - Optical fiber sensors

KW - Optical fibers

KW - Probes

KW - Scanning electron microscopy

KW - Sensitivity

KW - cardiac troponin I

KW - cerium oxide nanoparticles

KW - gold nanoparticles

KW - hetro-core fiber structure

KW - localized surface plasmon resonance

UR - https://www.scopus.com/pages/publications/85135225519

U2 - 10.1109/tnb.2022.3192491

DO - 10.1109/tnb.2022.3192491

M3 - Article

SN - 1536-1241

VL - 22

SP - 375

EP - 382

JO - IEEE Transactions on Nanobioscience

JF - IEEE Transactions on Nanobioscience

IS - 2

ER -

Cardiac Troponin I Detection using Gold/Cerium-Oxide Nanoparticles assisted Hetro-Core Fiber Structure

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Keywords

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