TY - JOUR
T1 - Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD
AU - Georgiopoulou, Vasiliki V.
AU - Dimopoulos, Stavros
AU - Sakellariou, Dimitrios
AU - Papazachou, Ourania
AU - Gerovasili, Vasiliki
AU - Tasoulis, Athanasios
AU - Agapitou, Varvara
AU - Vogiatzis, Ioannis
AU - Roussos, Charis
AU - Nanas, Serafim
PY - 2012/12
Y1 - 2012/12
N2 - BACKGROUND: Autonomic dysfunction is present early in the course of COPD, and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD. METHODS: We evaluated 45 stable subjects with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Subjects underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery. Heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery. RESULTS: Thirty-nine subjects (age 66.3±7.8 y, 90% male, body mass index 27.1±4.1 kg/m2, FEV1 45.7±18.7%) completed the program. In these subjects, heart rate recovery increased from 16.2 8.0 beats/min to 18.4 8.4 beats/min (P =.01), resting heart rate decreased from 88.0 10.7 beats/min to 83.3±10.5 beats/min (P =.004), and heart rate at anaerobic threshold decreased from 109.0 12.5 beats/min to 105.5 11.7 beats/min (P =.040). In addition, oxygen consumption (VO2) increased from 14.323.7 mL/kg/min to 15.2±3.8 mL/kg/min at peak exercise, and from 9.7±2.4 mL/kg/min to 10.4 while the VO2 /t slope increased from - 0.32 2.6 mL/kg/min at anaerobic threshold (both P =.02), 0.16 mL/kg/min2 to - 0.38±0.19 mL/kg/min2 (P =.003).2 Parameters of ventilatory performance improved also. CONCLUSIONS: In subjects with COPD, exercise-based rehabilitation improves heart rate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by V̇O2/t slope, is also improved
AB - BACKGROUND: Autonomic dysfunction is present early in the course of COPD, and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD. METHODS: We evaluated 45 stable subjects with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Subjects underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery. Heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery. RESULTS: Thirty-nine subjects (age 66.3±7.8 y, 90% male, body mass index 27.1±4.1 kg/m2, FEV1 45.7±18.7%) completed the program. In these subjects, heart rate recovery increased from 16.2 8.0 beats/min to 18.4 8.4 beats/min (P =.01), resting heart rate decreased from 88.0 10.7 beats/min to 83.3±10.5 beats/min (P =.004), and heart rate at anaerobic threshold decreased from 109.0 12.5 beats/min to 105.5 11.7 beats/min (P =.040). In addition, oxygen consumption (VO2) increased from 14.323.7 mL/kg/min to 15.2±3.8 mL/kg/min at peak exercise, and from 9.7±2.4 mL/kg/min to 10.4 while the VO2 /t slope increased from - 0.32 2.6 mL/kg/min at anaerobic threshold (both P =.02), 0.16 mL/kg/min2 to - 0.38±0.19 mL/kg/min2 (P =.003).2 Parameters of ventilatory performance improved also. CONCLUSIONS: In subjects with COPD, exercise-based rehabilitation improves heart rate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by V̇O2/t slope, is also improved
KW - Autonomic nervous system
KW - COPD
KW - Ergometry/exercise test
KW - Heart rate
KW - Rehabilitation/exercise therap
UR - http://www.scopus.com/inward/record.url?scp=84870809686&partnerID=8YFLogxK
U2 - 10.4187/respcare.01485
DO - 10.4187/respcare.01485
M3 - Article
C2 - 22710548
AN - SCOPUS:84870809686
SN - 0020-1324
VL - 57
SP - 2095
EP - 2103
JO - Respiratory Care
JF - Respiratory Care
IS - 12
ER -