A working group on Greenland Ice Sheet-Ocean Interactions (GRISO), composed of representatives from the multiple disciplines involved, was established in January 2011 to develop strategies to address dynamic response of Greenland's glaciers to climate forcing. Critical aspects of Greenland's coupled ice sheet-ocean system are identified, and a research agenda is outlined that will yield fundamental insights into how the ice sheet and ocean interact, their role in Earth's climate system, their regional and global effects, and probable trajectories of future changes. Key elements of the research agenda are focused process studies, sustained observational efforts at key sites, and inclusion of the relevant dynamics in Earth system models. Interdisciplinary and multiagency efforts, as well as international cooperation, are crucial to making progress on this novel and complex problem. This will prove as a significant step toward fulfilling the goal of credibly projecting sea level rise over the coming decades and century.