Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms

Mírian C. M. M. David, Marina S. B. Mattos, Jandirlly J. S. Souto, Sarah A. C. F. Brito, Etcheverry S. Leite, Eduardo N. Valença, Gilma S. Galdino, Patrick G. G. Sampaio, Daniel M. C. Moura, Mário A. L. Miguel, John F. Araújo, Carlúcia I. F. Franco, Rhowena J. B. Matos*

*Corresponding author for this work

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Abstract

OBJECTIVE: To characterize rest-activity rhythm in chronic migraine (CM) and to investigate the relationship between this rhythm and depressive and anxiety symptoms in patients with CM.
METHODS: This was a study of adults aged 20 to 40 years. The rest-activity rhythm of patients with CM (n=23) and non-headache controls (NH, n=23) was assessed by actigraphy for 15 days, and they completed the following assessments: Visual Analogue Scale for pain intensity; Headache Diary; Headache Impact Test-6; Morningness-Eveningness Questionnaire; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Beck Depression Inventory; and State-Trait Anxiety Inventory.
RESULTS: Patients with CM showed less activity over 24 hours and more fragmented sleep. Reduced interdaily stability of the rest-activity rhythm was observed, with less robustness of this rhythm in the CM group. Multiple linear regressions revealed a significant association between the rest-activity rhythm and trait anxiety variables in patients with CM, specifically regarding the relative amplitude of the cycle, activity throughout 24 hours and during sleep, and robustness of the rest-activity rhythm.
CONCLUSIONS: Our findings provide evidence that the robustness of the rest-activity rhythm, activity throughout 24 hours, and sleep fragmentation are associated with trait anxiety in patients with CM.
CLINICAL TRIAL REGISTRATION: Brazilian Clinical Trials Registry (registration number: RBR-4M5J4S).
Original languageEnglish
Pages (from-to)611-620
Number of pages10
JournalBrazilian Journal of Psychiatry
Volume44
Issue number6
Early online date7 Oct 2022
DOIs
Publication statusPublished - 24 Oct 2022
Externally publishedYes

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