Changes in the substance P-containing innervation of the lumbosacral spinal cord in male Wistar rats as a consequence of ageing

Richard Ranson; David Priestley; Robert Santer; Alan Watson

doi:10.1016/j.brainres.2004.12.031

Changes in the substance P-containing innervation of the lumbosacral spinal cord in male Wistar rats as a consequence of ageing

Richard Ranson, David Priestley, Robert Santer, Alan Watson

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Substance P is implicated in controlling micturition reflexes. This investigation revealed Substance P immunoreactive terminals which markedly declined in spinal regions associated with bladder emptying/storage that were not replicated in regions associated with sphincter control. This observation reinforces concepts of ‘differential susceptibility’ to ageing in terms of axon pathology.

Original language	English
Pages (from-to)	139-144
Journal	Brain Research
Volume	1036
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2004.12.031
Publication status	Published - Mar 2005

Keywords

dorsolateral nucleus
image analysis
immunocytochemistry
micturition

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10.1016/j.brainres.2004.12.031

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title = "Changes in the substance P-containing innervation of the lumbosacral spinal cord in male Wistar rats as a consequence of ageing",

abstract = "Substance P is implicated in controlling micturition reflexes. This investigation revealed Substance P immunoreactive terminals which markedly declined in spinal regions associated with bladder emptying/storage that were not replicated in regions associated with sphincter control. This observation reinforces concepts of {\textquoteleft}differential susceptibility{\textquoteright} to ageing in terms of axon pathology.",

keywords = "dorsolateral nucleus, image analysis, immunocytochemistry, micturition",

author = "Richard Ranson and David Priestley and Robert Santer and Alan Watson",

year = "2005",

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AU - Ranson, Richard

AU - Priestley, David

AU - Santer, Robert

AU - Watson, Alan

PY - 2005/3

Y1 - 2005/3

N2 - Substance P is implicated in controlling micturition reflexes. This investigation revealed Substance P immunoreactive terminals which markedly declined in spinal regions associated with bladder emptying/storage that were not replicated in regions associated with sphincter control. This observation reinforces concepts of ‘differential susceptibility’ to ageing in terms of axon pathology.

AB - Substance P is implicated in controlling micturition reflexes. This investigation revealed Substance P immunoreactive terminals which markedly declined in spinal regions associated with bladder emptying/storage that were not replicated in regions associated with sphincter control. This observation reinforces concepts of ‘differential susceptibility’ to ageing in terms of axon pathology.

KW - dorsolateral nucleus

KW - image analysis

KW - immunocytochemistry

KW - micturition

UR - https://www.scopus.com/pages/publications/13844253812

U2 - 10.1016/j.brainres.2004.12.031

DO - 10.1016/j.brainres.2004.12.031

M3 - Article

SN - 0006-8993

VL - 1036

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EP - 144

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Changes in the substance P-containing innervation of the lumbosacral spinal cord in male Wistar rats as a consequence of ageing

Abstract

Keywords

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