Chipset Nanosensor Based on N‐Doped Carbon Nanobuds for Selective Screening of Epinephrine in Human Samples

Mohammed Y. Emran, Sherif A. El-Safty*, Ahmed Elmarakbi, Abduallah Reda, Ayman El Sabagh, Mohamed A. Shenashen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chipset nanosensor design and fabrication are important for healthcare research and development. Herein, a functionalized chipset nanosensor is designed to monitor neurotransmitters (i.e., epinephrine (EP)) in human fluids. An interdigitated electrode array (IDA) is functionalized by N-doped carbon nanobud (N-CNB) and N-doped carbon nanostructure (N-CNS). The surface morphology of N-CNB shows the formation of nanotubular-like branches on sheets and micrometer-size tubes. The N-CNS design consists of the formation of aggregated sheets and particles in nanometer size. The irregular shape formation provides surface heterogeneity and numerous free spaces between the stacked nanostructures. N-atoms ascertain highly active N-CNS with multifunctional active centers, electron-rich charged surface, and short distance pathway. The N-CNB/IDA exhibits the best performance for EP signaling with high sensitivity and selectivity. The N-CNB/IDA sensing performance for EP detection indicates the successful design of a highly selective and sensitive assay with low detection limit of 0.011 × 10−6 m and a broad linear range of 0.5 × 10−6 to 3 × 10−6 m. The N-CNB/IDA exhibits a high degree of accuracy and reproducibility with RSD of 2.7% and 3.9%, respectively. Therefore, the chipset nanosensor of N-CNB/IDA can be used for on-site monitoring of EP in human serum samples and further used in daily monitoring of neuronal disorders.
Original languageEnglish
Article number2101473
Number of pages13
JournalAdvanced Materials Interfaces
Volume9
Issue number1
Early online date23 Nov 2021
DOIs
Publication statusPublished - 5 Jan 2022

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