TY - JOUR
T1 - Cognitive and neural processes in non-clinical auditory hallucinations
AU - Barkus, Emma
AU - Stirling, John
AU - Hopkins, Richard
AU - McKie, Shane
AU - Lewis, Shôn
PY - 2007/12
Y1 - 2007/12
N2 - BACKGROUND: The nosological status of auditory hallucinations in non-clinical samples is unclear.AIMS: To investigate the functional neural basis of non-clinical hallucinations.METHOD: After selection from 1206 people, 68 participants of high, medium and low hallucination proneness completed a task designed to elicit verbal hallucinatory phenomena under conditions of stimulus degradation. Eight subjects who reported hearing a voice when none was present repeated the task during functional imaging.RESULTS: During the signal detection task, the high hallucination-prone participants reported a voice to be present when it was not (false alarms) significantly more often than the average or low participants (P<0.03, d.f.=2). On functional magnetic resonance imaging, patterns of activation during these false alarms showed activation in the superior and middle temporal cortex (P<0.001).CONCLUSIONS: Auditory hallucinatory experiences reported in non-clinical samples appear to be mediated by similar patterns of cerebral activation as found during hallucinations in schizophrenia.
AB - BACKGROUND: The nosological status of auditory hallucinations in non-clinical samples is unclear.AIMS: To investigate the functional neural basis of non-clinical hallucinations.METHOD: After selection from 1206 people, 68 participants of high, medium and low hallucination proneness completed a task designed to elicit verbal hallucinatory phenomena under conditions of stimulus degradation. Eight subjects who reported hearing a voice when none was present repeated the task during functional imaging.RESULTS: During the signal detection task, the high hallucination-prone participants reported a voice to be present when it was not (false alarms) significantly more often than the average or low participants (P<0.03, d.f.=2). On functional magnetic resonance imaging, patterns of activation during these false alarms showed activation in the superior and middle temporal cortex (P<0.001).CONCLUSIONS: Auditory hallucinatory experiences reported in non-clinical samples appear to be mediated by similar patterns of cerebral activation as found during hallucinations in schizophrenia.
KW - Acoustic Stimulation/methods
KW - Adolescent
KW - Adult
KW - Auditory Perceptual Disorders/physiopathology
KW - Brain Mapping/methods
KW - Female
KW - Hallucinations/physiopathology
KW - Humans
KW - Image Processing, Computer-Assisted/methods
KW - Magnetic Resonance Imaging/methods
KW - Male
KW - Marijuana Smoking/psychology
KW - Reaction Time
KW - Schizophrenic Psychology
KW - Signal Detection, Psychological
KW - Temporal Lobe/physiopathology
U2 - 10.1192/bjp.191.51.s76
DO - 10.1192/bjp.191.51.s76
M3 - Article
C2 - 18055942
VL - 51
SP - 76
EP - 81
JO - The British journal of psychiatry. Supplement
JF - The British journal of psychiatry. Supplement
SN - 0960-5371
ER -