TY - JOUR
T1 - Cohort profile
T2 - The Baependi Heart Study - A family-based, highly admixed cohort study in a rural Brazilian town
AU - Egan, Kieren J.
AU - Von Schantz, Malcolm
AU - Negrão, André B.
AU - Santos, Hadassa C.
AU - Horimoto, Andréa R.V.R.
AU - Duarte, Nubia E.
AU - Gonçalves, Guilherme C.
AU - Soler, Júlia M.P.
AU - De Andrade, Mariza
AU - Lorenzi-Filho, Geraldo
AU - Vallada, Homero
AU - Taporoski, Tâmara P.
AU - Pedrazzoli, Mario
AU - Azambuja, Ana P.
AU - De Oliveira, Camila M.
AU - Alvim, Rafael O.
AU - Krieger, José E.
AU - Pereira, Alexandre C.
N1 - Funding Information:
This study was supported by awards from FAPESP to ACP, JEK, ARVRH and MP (grants 2007/58150-7, 2010/51010-8, 2011/05804-5, 2013/17368-0), from CNPq to ACP, JEK, HV, ARVRH and MvS (150653/2008-5, 481304/2012-6, and 400791/2015-5), Funda??o Zerbini and Hospital Samaritano, and by the Global Innovation Initiative to MvS (jointly funded by the British Council and the UK Department of Business and Skills).
PY - 2016/10/21
Y1 - 2016/10/21
N2 - Purpose: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestylerelated peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits. Participants: Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Crosssectional data have been collected for 2239 participants. Findings to date: Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas. Future plans: A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.
AB - Purpose: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestylerelated peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits. Participants: Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Crosssectional data have been collected for 2239 participants. Findings to date: Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas. Future plans: A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.
UR - http://www.scopus.com/inward/record.url?scp=84992616387&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2016-011598
DO - 10.1136/bmjopen-2016-011598
M3 - Review article
C2 - 27797990
AN - SCOPUS:84992616387
SN - 2044-6055
VL - 6
JO - BMJ Open
JF - BMJ Open
IS - 10
M1 - e011598
ER -
