Combining Photochemistry and Catalysis: Rapid Access to sp3 – rich Polyheterocycles from Simple Pyrroles

Emma Blackham, Jonathan Knowles, Jonathan Burgess, Kevin Booker-Milburn

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
6 Downloads (Pure)

Abstract

Use of FEP flow reactor technology allows access to gram quantities of photochemically-generated tricyclic aziridines. These undergo a range of novel palladium-catalyzed ring-opening and cycloaddition reactions, likely driven by their inherent strain, allowing incorporation of further functionality by fusing additional heterocyclic rings onto these already complex polycyclic cores. This rapid, 2-step access to complex sp3 – rich heterocycles should be of interest to those in the fields of drug discovery and natural product synthesis.
Original languageEnglish
Pages (from-to)2302-2307
JournalChemical Science
Volume7
Issue number3
Early online date4 Jan 2016
DOIs
Publication statusPublished - 1 Mar 2016

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