Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively

Kevin J. Molloy; Matt M. Thompson; Edward C. Schwalbe; Peter R.F. Bell; A. Ross Naylor; Ian M. Loftus

doi:10.1016/j.amjcard.2004.03.050

Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively

Kevin J. Molloy, Matt M. Thompson, Edward C. Schwalbe, Peter R.F. Bell, A. Ross Naylor, Ian M. Loftus^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).

Original language	English
Pages (from-to)	144-146
Number of pages	3
Journal	American Journal of Cardiology
Volume	94
Issue number	1
Early online date	23 Jun 2004
DOIs	https://doi.org/10.1016/j.amjcard.2004.03.050
Publication status	Published - 1 Jul 2004
Externally published	Yes

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Molloy, K. J., Thompson, M. M., Schwalbe, E. C., Bell, P. R. F., Naylor, A. R., & Loftus, I. M. (2004). Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively. American Journal of Cardiology, 94(1), 144-146. https://doi.org/10.1016/j.amjcard.2004.03.050

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title = "Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively",

abstract = "We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).",

author = "Molloy, {Kevin J.} and Thompson, {Matt M.} and Schwalbe, {Edward C.} and Bell, {Peter R.F.} and Naylor, {A. Ross} and Loftus, {Ian M.}",

note = "Funding Information: This study was funded by the United Kingdom Stroke Association, London, United Kingdom. ",

year = "2004",

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doi = "10.1016/j.amjcard.2004.03.050",

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Molloy, KJ, Thompson, MM, Schwalbe, EC, Bell, PRF, Naylor, AR & Loftus, IM 2004, 'Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively', American Journal of Cardiology, vol. 94, no. 1, pp. 144-146. https://doi.org/10.1016/j.amjcard.2004.03.050

Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively. / Molloy, Kevin J.; Thompson, Matt M.; Schwalbe, Edward C. et al.
In: American Journal of Cardiology, Vol. 94, No. 1, 01.07.2004, p. 144-146.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively

AU - Molloy, Kevin J.

AU - Thompson, Matt M.

AU - Schwalbe, Edward C.

AU - Bell, Peter R.F.

AU - Naylor, A. Ross

AU - Loftus, Ian M.

N1 - Funding Information: This study was funded by the United Kingdom Stroke Association, London, United Kingdom.

PY - 2004/7/1

Y1 - 2004/7/1

N2 - We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).

AB - We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).

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DO - 10.1016/j.amjcard.2004.03.050

M3 - Article

C2 - 15219530

AN - SCOPUS:3042613500

SN - 0002-9149

VL - 94

SP - 144

EP - 146

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 1

ER -

Molloy KJ, Thompson MM, Schwalbe EC, Bell PRF, Naylor AR, Loftus IM. Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively. American Journal of Cardiology. 2004 Jul 1;94(1):144-146. Epub 2004 Jun 23. doi: 10.1016/j.amjcard.2004.03.050

Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively

Abstract

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