One of the most significant chemical processes for forming complexes is complexation. Various thermodynamic changes occur during the creation of complexes, which have been examined at various temperatures using various methodologies. The goal of this paper is to provide a general overview of antibiotic-metal ion interactions. How does vary the stability constants and it influences the complex formation. In terms of biological significance, changes in the values of thermodynamic properties like free energy (ΔGo), enthalpy (ΔHo), and entropy (ΔSo) are far more crucial to the development of complexes. This study is very useful for complexation properties as well as stabilities of antibiotics with metal ions.