TY - JOUR
T1 - Comprehensive Analysis of Drugs to Treat SARS‑CoV‑2 Infection: Mechanistic Insights Into Current COVID‑19 Therapies (Review)
AU - Nitulescu, George
AU - Paunescu, Horia
AU - Moschos, Sterghios
AU - Petrakis, Dimitrios
AU - Nitulescu, Georgiana
AU - Ion, George
AU - Spandidos, Demetrios A.
AU - Nikolouzakis, Taxiarchis
AU - Drakoulis, Nikolaos
AU - Tsatsakis, Aristidis
PY - 2020/8
Y1 - 2020/8
N2 - The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID‑19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID‑19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.
AB - The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID‑19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID‑19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.
KW - COVId-19
KW - Drug testing
KW - SARS-CoV-2
KW - Treatment strategies
UR - http://www.scopus.com/inward/record.url?scp=85087110634&partnerID=8YFLogxK
U2 - 10.3892/ijmm.2020.4608
DO - 10.3892/ijmm.2020.4608
M3 - Review article
C2 - 32468014
SN - 1107-3756
VL - 46
SP - 467
EP - 488
JO - International Journal of Molecular Medicine
JF - International Journal of Molecular Medicine
IS - 2
ER -