Compromised arterial oxygen saturation in elderly asthma sufferers results in selective cognitive impairment

Mark Moss, Mark Franks, Pamela Briggs, David Kennedy, Andrew Scholey

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Forty elderly patients with asthma or chronic obstructive pulmonary disorder (COPD) were compared to a comparison group of forty age-matched healthy volunteers on a range of measures of cognitive performance, and levels of arterial haemoglobin oxygen saturation recorded. Members of the patient group were found to have significantly lower oxygen saturation compared to the comparison group, and performed significantly poorer on tests of delayed word recall and serial subtractions, but not on other tasks. Correlational analysis between participants' oxygen saturation levels and test scores across the whole sample indicated significant positive relationships existed for the digit symbol substitution and serial subtractions tasks. The results are discussed in terms of cerebral oxygen delivery, glucose metabolism, age related cognitive decline, and relative task demands.
Original languageEnglish
Pages (from-to)139-150
JournalJournal of Clinical and Experimental Neuropsychology
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2005

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