Abstract
OBJECTIVE: To explore whether people with lower-limb tendinopathy have reduced relative conditioned pain modulation (CPM) when compared to nontendinopathy controls.
DESIGN: Systematic review with individual participant data (IPD) meta-analysis.
LITERATURE SEARCH: Eight databases were searched until August 29, 2022.
STUDY SELECTION CRITERIA: Cross-sectional studies comparing the magnitude of the CPM effect in people with lower-limb tendinopathy to nontendinopathy controls in a case-control design.
DATA SYNTHESIS: Included studies provided IPD, which was reported using descriptive statistics. Generalized estimating equations (GEEs) determined between-group differences in the relative CPM effect, when adjusting for co-variables. Study quality was assessed using a Joanna Briggs Institute checklist, and certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluations.
RESULTS: Five records were included, IPD were provided for 4 studies (n = 219 with tendinopathy, n = 226 controls). The principal GEE (model 1) found no significant relative CPM effects for tendinopathy versus controls (B = −1.73, P = .481). Sex (B = 4.11, P = .160), age (B = −0.20, P = .109), and body mass index (B = 0.28, P = .442) did not influence relative CPM effect. The Achilles region had a reduced CPM effect (B = −22.01, P = .009). In model 2 (adjusting for temperature), temperature (B = −2.86, P = .035) and female sex (B = 21.01, P = .047) were associated with the size of the relative CPM effect. All studies were low-quality, and the certainty of the evidence was moderate.
CONCLUSION: There were no between-group differences in the magnitude of the CPM effect, suggesting clinicians should manage lower-limb tendinopathy using interventions appropriate for peripherally dominant pain (eg, tendon loading exercises such as heavy slow resistance). Based on the “moderate”-certainty evidence, future studies are unlikely to substantially change these findings.
DESIGN: Systematic review with individual participant data (IPD) meta-analysis.
LITERATURE SEARCH: Eight databases were searched until August 29, 2022.
STUDY SELECTION CRITERIA: Cross-sectional studies comparing the magnitude of the CPM effect in people with lower-limb tendinopathy to nontendinopathy controls in a case-control design.
DATA SYNTHESIS: Included studies provided IPD, which was reported using descriptive statistics. Generalized estimating equations (GEEs) determined between-group differences in the relative CPM effect, when adjusting for co-variables. Study quality was assessed using a Joanna Briggs Institute checklist, and certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluations.
RESULTS: Five records were included, IPD were provided for 4 studies (n = 219 with tendinopathy, n = 226 controls). The principal GEE (model 1) found no significant relative CPM effects for tendinopathy versus controls (B = −1.73, P = .481). Sex (B = 4.11, P = .160), age (B = −0.20, P = .109), and body mass index (B = 0.28, P = .442) did not influence relative CPM effect. The Achilles region had a reduced CPM effect (B = −22.01, P = .009). In model 2 (adjusting for temperature), temperature (B = −2.86, P = .035) and female sex (B = 21.01, P = .047) were associated with the size of the relative CPM effect. All studies were low-quality, and the certainty of the evidence was moderate.
CONCLUSION: There were no between-group differences in the magnitude of the CPM effect, suggesting clinicians should manage lower-limb tendinopathy using interventions appropriate for peripherally dominant pain (eg, tendon loading exercises such as heavy slow resistance). Based on the “moderate”-certainty evidence, future studies are unlikely to substantially change these findings.
| Original language | English |
|---|---|
| Pages (from-to) | 50-59 |
| Number of pages | 10 |
| Journal | Journal of Orthopaedic and Sports Physical Therapy |
| Volume | 54 |
| Issue number | 1 |
| Early online date | 17 Nov 2023 |
| DOIs | |
| Publication status | Published - 1 Jan 2024 |
Keywords
- exercise
- muscle
- pain
- rehabilitation
- tendon