Connective tissue diseases: Nucleosomes and systemic sclerosis

Steven O'Reilly, Jacob van Laar

Research output: Contribution to journalBook/Film/Article reviewpeer-review

1 Citation (Scopus)

Abstract

Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis. http://dx.doi.org/10.1136/
annrheumdis-2015-207405
Original languageEnglish
Pages (from-to)138-139
JournalNature Reviews Rheumatology
Volume12
Issue number3
Early online date4 Feb 2016
DOIs
Publication statusPublished - Mar 2016

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