Abstract
Systemic sclerosis (SSc) is characterized by an abnormal immune response to innocuous antigens that might lead to autoantibody production. New observations suggest that nucleosomes can mediate both IgG production and B-cell proliferation, via Toll-like receptor signalling, and thereby affect the pathogenesis of SSc.
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis. http://dx.doi.org/10.1136/
annrheumdis-2015-207405
Refers to Yoshizaki, A. et al. Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. Ann. Rheum. Dis. http://dx.doi.org/10.1136/
annrheumdis-2015-207405
Original language | English |
---|---|
Pages (from-to) | 138-139 |
Journal | Nature Reviews Rheumatology |
Volume | 12 |
Issue number | 3 |
Early online date | 4 Feb 2016 |
DOIs | |
Publication status | Published - Mar 2016 |
Keywords
- Clinical epigenetics
- Immunopathogenesis
- Molecular medicine
- Systemic sclerosis