Continuous computation in engineered gene circuits

Angel Goñi-Moreno*, Martyn Amos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

In this paper we consider the problem of representation and measurement in genetic circuits, and investigate how they can affect the reliability of engineered systems. We propose a design scheme, based on the notion of continuous computation, which addresses these issues. We illustrate the methodology by showing how a concept from computer architecture (namely, branch prediction) may be implemented in vivo, using a distributed approach. Simulation results confirm the in-principle feasibility of our method, and offer valuable insights into its future laboratory validation.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalBioSystems
Volume109
Issue number1
Early online date23 Feb 2012
DOIs
Publication statusPublished - 1 Jul 2012

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