Corynebacterium diphtheriae is the etiological agent of diphtheria; an acute toxin-mediated infection of the upper respiratory tract and skin. The toxin gene is encoded on a temperate bacteriophage, which during lysogeny is capable of toxin production. In this chapter, we will summarise current knowledge regarding corynephage, focusing on the lifecycle and biology of the toxin-carrying corynephages that are known to convert pathogenic corynebacteria, and discuss the insights recent genome corynebacterial sequencing has given us.
|Title of host publication||Corynebacterium diphtheriae and Related Toxigenic Species: Genomics, Pathogenicity and Applications|
|Place of Publication||London|
|Publication status||Published - 1 Jan 2014|