Abstract
Purpose: Patient-reported fatigue after robotic-assisted radical prostatectomy (RARP) has not been characterised to date. Fatigue after other prostate cancer (PCa) treatments is known to impact on patient-reported quality of life. The aim of this study was to characterise fatigue, physical activity levels and cardiovascular status post-RARP.
Methods: Between October 2016 and March 2017, men post-RARP or on androgen deprivation therapy (ADT) were invited into the study. Participants were asked to complete the Brief Fatigue Inventory (BFI), Stage of Change and Scottish Physical Activity Questionnaires (SPAQ) over a two-week period. Outcome measures were patient reported fatigue, physical activity levels and the 10-year risk of cardiovascular disease (QRisk). Data were analysed in SPSS.
Results: 96/117 (82%) men approached consented to participate, of these 62/96 (65%) returned complete questionnaire data (RARP n = 42, ADT n = 20). All men reported fatigue with 9/42 (21%) post-RARP reporting clinically significant fatigue. Physical activity did not correlate with fatigue. On average, both groups were overweight (BMI 27.0 ± 3.9kg/m2 and 27.8 ± 12.3kg/m2 for RARP and ADT respectively) and the post-RARP group had an 18.1% ± 7.4% QRisk2 score.
Conclusions: A proportion of men are at increased risk of cardiovascular disease within 10 years post-RARP and have substantial levels of fatigue therefore, clinicians should consider including these factors when counselling patients about RARP. Additionally, men post-RARP did not meet the recommended guidelines for resistance-based exercise. Future research is needed to establish whether interventions including resistance-based exercise can improve health and fatigue levels in this population.
Methods: Between October 2016 and March 2017, men post-RARP or on androgen deprivation therapy (ADT) were invited into the study. Participants were asked to complete the Brief Fatigue Inventory (BFI), Stage of Change and Scottish Physical Activity Questionnaires (SPAQ) over a two-week period. Outcome measures were patient reported fatigue, physical activity levels and the 10-year risk of cardiovascular disease (QRisk). Data were analysed in SPSS.
Results: 96/117 (82%) men approached consented to participate, of these 62/96 (65%) returned complete questionnaire data (RARP n = 42, ADT n = 20). All men reported fatigue with 9/42 (21%) post-RARP reporting clinically significant fatigue. Physical activity did not correlate with fatigue. On average, both groups were overweight (BMI 27.0 ± 3.9kg/m2 and 27.8 ± 12.3kg/m2 for RARP and ADT respectively) and the post-RARP group had an 18.1% ± 7.4% QRisk2 score.
Conclusions: A proportion of men are at increased risk of cardiovascular disease within 10 years post-RARP and have substantial levels of fatigue therefore, clinicians should consider including these factors when counselling patients about RARP. Additionally, men post-RARP did not meet the recommended guidelines for resistance-based exercise. Future research is needed to establish whether interventions including resistance-based exercise can improve health and fatigue levels in this population.
| Original language | English |
|---|---|
| Pages (from-to) | 4763-4770 |
| Number of pages | 8 |
| Journal | Supportive Care in Cancer |
| Volume | 27 |
| Issue number | 12 |
| Early online date | 10 Apr 2019 |
| DOIs | |
| Publication status | Published - 1 Dec 2019 |
