General design procedures for prestressed stayed columns with a single cross-arm system are presented. The accuracy of the proposed design expressions is confirmed by comparison with the results of physical experiments and validated finite element simulations. Reliability is assessed by following the approach set out in Annex D of EN 1990. The presented resistance expressions for prestressed stayed columns are a function of the system geometry, the level of initial prestress in the cables and the global imperfection level. Worked examples are also presented to illustrate the application of the developed design approach.