Designing Genetic Feedback Controllers

Andreas W.K. Harris; James A. Dolan; Ciarán L. Kelly; James Anderson; Antonis Papachristodoulou

doi:10.1109/TBCAS.2015.2458435

Designing Genetic Feedback Controllers

Andreas W.K. Harris, James A. Dolan, Ciarán L. Kelly, James Anderson^*, Antonis Papachristodoulou

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

By incorporating feedback around systems we wish to manipulate, it is possible to improve their performance and robustness properties to meet pre-specified design objectives. For decades control engineers have been successfully implementing feedback controllers for complex mechanical and electrical systems such as aircraft and sports cars. Natural biological systems use feedback extensively for regulation and adaptation but apart from the most basic designs, there is no systematic framework for designing feedback controllers in Synthetic Biology. In this paper we describe how classical approaches from linear control theory can be used to close the loop. This includes the design of genetic circuits using feedback control and the presentation of a biological phase lag controller.

Original language	English
Article number	7265107
Pages (from-to)	475-484
Number of pages	10
Journal	IEEE Transactions on Biomedical Circuits and Systems
Volume	9
Issue number	4
DOIs	https://doi.org/10.1109/TBCAS.2015.2458435
Publication status	Published - 14 Aug 2015
Externally published	Yes

Keywords

Feedback control
robust control
systems and synthetic biology

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10.1109/TBCAS.2015.2458435

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Designing Genetic Feedback Controllers

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Keywords

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