Desymmetrization of dichloroazaheterocycles

Allan Goodman, Stephen Stanforth, Brian Tarbit

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

3,6-Dichloropyridizine 1a was converted in good yield into its mono-iodo derivative 1b when treated with a mixture of hydriodic acid and sodium iodide. Pure samples of the mono-iodo derivatives 2b, 3b and 4b could not be obtained from their corresponding dichlorinated precursors with these reagents. Compounds 1b and 4b underwent palladium catalysed Suzuki, Sonogashira and other coupling reactions.
Original languageEnglish
Pages (from-to)15067-15070
JournalTetrahedron
Volume55
Issue number52
DOIs
Publication statusPublished - 24 Dec 1999

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