Detection of L-alanylaminopeptidase activity in microorganisms using chromogenic self-immolative enzyme substrates

Marie Cellier, Arthur James, Sylvain Orenga, John Perry, Ari Rasul, Stephen Stanforth

Research output: Contribution to journalArticlepeer-review

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Abstract

Three potential chromogenic enzymatic probes, each possessing a self-immolative spacer unit, were synthesised for the purpose of detecting L-alanylaminopeptidase activity in microorganisms. An Alizarin-based probe was the most effective, allowing several species to generate strongly coloured colonies in the presence of metal ions.
Original languageEnglish
Pages (from-to)2102-2106
JournalBioorganic & Medicinal Chemistry Letters
Volume27
Issue number10
Early online date28 Mar 2017
DOIs
Publication statusPublished - 15 May 2017

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