Determination of octanol-water partition coefficients using gradient liquid chromatography

Valeria Vladimirovna Makovskaya, John Dean, William Tomlinson, Steven Hitchen, Michael Comber

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.
Original languageEnglish
Pages (from-to)183-192
JournalAnalytica Chimica Acta
Issue number1-2
Publication statusPublished - Oct 1995


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