TY - JOUR
T1 - Determination of octanol-water partition coefficients using gradient liquid chromatography
AU - Makovskaya, Valeria Vladimirovna
AU - Dean, John
AU - Tomlinson, William
AU - Hitchen, Steven
AU - Comber, Michael
PY - 1995/10
Y1 - 1995/10
N2 - The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.
AB - The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.
KW - Environmental analysis
KW - Liquid chromatography
KW - Octanol-water partition coefficient
UR - https://www.scopus.com/pages/publications/0028829498
U2 - 10.1016/0003-2670(95)00295-B
DO - 10.1016/0003-2670(95)00295-B
M3 - Article
SN - 0003-2670
VL - 315
SP - 183
EP - 192
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
IS - 1-2
ER -