Determination of octanol-water partition coefficients using gradient liquid chromatography

Valeria Vladimirovna Makovskaya; John Dean; William Tomlinson; Steven Hitchen; Michael Comber

doi:10.1016/0003-2670(95)00295-B

Determination of octanol-water partition coefficients using gradient liquid chromatography

Valeria Vladimirovna Makovskaya, John Dean, William Tomlinson, Steven Hitchen, Michael Comber

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.

Original language	English
Pages (from-to)	183-192
Journal	Analytica Chimica Acta
Volume	315
Issue number	1-2
DOIs	https://doi.org/10.1016/0003-2670(95)00295-B
Publication status	Published - Oct 1995

Keywords

Environmental analysis
Liquid chromatography
Octanol-water partition coefficient

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10.1016/0003-2670(95)00295-B

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title = "Determination of octanol-water partition coefficients using gradient liquid chromatography",

abstract = "The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100\% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.",

keywords = "Environmental analysis, Liquid chromatography, Octanol-water partition coefficient",

author = "Makovskaya, \{Valeria Vladimirovna\} and John Dean and William Tomlinson and Steven Hitchen and Michael Comber",

year = "1995",

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doi = "10.1016/0003-2670(95)00295-B",

language = "English",

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pages = "183--192",

journal = "Analytica Chimica Acta",

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T1 - Determination of octanol-water partition coefficients using gradient liquid chromatography

AU - Makovskaya, Valeria Vladimirovna

AU - Dean, John

AU - Tomlinson, William

AU - Hitchen, Steven

AU - Comber, Michael

PY - 1995/10

Y1 - 1995/10

N2 - The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.

AB - The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. The capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w) correlates well with both literature and isocratic LC-generated log k(ow) values. The gradient LC method could be extended to a wider range of test compounds.

KW - Environmental analysis

KW - Liquid chromatography

KW - Octanol-water partition coefficient

UR - https://www.scopus.com/pages/publications/0028829498

U2 - 10.1016/0003-2670(95)00295-B

DO - 10.1016/0003-2670(95)00295-B

M3 - Article

SN - 0003-2670

VL - 315

SP - 183

EP - 192

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

IS - 1-2

ER -

Determination of octanol-water partition coefficients using gradient liquid chromatography

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Keywords

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