Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

Florian Bender; Paul Roach; Achilleas Tsortos; George Papadakis; Michael Newton; Glen McHale; Electra Gizeli

doi:10.1088/0957-0233/20/12/124011

Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

Florian Bender, Paul Roach, Achilleas Tsortos, George Papadakis, Michael Newton, Glen McHale, Electra Gizeli

Mathematics, Physics and Electrical Engineering

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

18 Downloads (Pure)

Abstract

It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance/surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for the deposition of neutravidin and DNA are reported.

Original language	English
Pages (from-to)	124011
Journal	Measurement Science and Technology
Volume	20
Issue number	12
DOIs	https://doi.org/10.1088/0957-0233/20/12/124011
Publication status	Published - 26 Oct 2009

Keywords

SAW
SPR
biosensor
viscoelastic effects
biorecognition

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10.1088/0957-0233/20/12/124011

Postprint McHale MST vol 20 art 124011 2009Accepted author manuscript, 231 KB

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AU - Roach, Paul

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AU - Newton, Michael

AU - McHale, Glen

AU - Gizeli, Electra

PY - 2009/10/26

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N2 - It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance/surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for the deposition of neutravidin and DNA are reported.

AB - It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance/surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for the deposition of neutravidin and DNA are reported.

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KW - SPR

KW - biosensor

KW - viscoelastic effects

KW - biorecognition

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DO - 10.1088/0957-0233/20/12/124011

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JF - Measurement Science and Technology

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Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

Abstract

Keywords

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