Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

Florian Bender, Paul Roach, Achilleas Tsortos, George Papadakis, Michael Newton, Glen McHale, Electra Gizeli

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
5 Downloads (Pure)

Abstract

It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance/surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for the deposition of neutravidin and DNA are reported.
Original languageEnglish
Pages (from-to)124011
JournalMeasurement Science and Technology
Volume20
Issue number12
DOIs
Publication statusPublished - 26 Oct 2009

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