Development of ciprofloxacin-loaded contact lenses using fluorous chemistry

Guoting Qin, Zhiling Zhu, Siheng Li, Alison McDermott, Chengzhi Cai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

In this work, we developed a simple method to load drugs into commercially available contact lenses utilizing fluorous chemistry. We demonstrated this method using model compounds including fluorous-tagged fluorescein and antibiotic ciprofloxacin. We showed that fluorous interactions facilitated the loading of model molecules into fluorocarbon-containing contact lenses, and that the release profiles exhibited sustained release. Contact lenses loaded with fluorous-tagged ciprofloxacin exhibited antimicrobial activity against Pseudomonas aeruginosa in vitro, while no cytotoxicity towards human corneal epithelial cells was observed. To mimic the tear turnover, we designed a porcine eye infection model under flow conditions. Significantly, the modified lenses also exhibited antimicrobial efficacy against Pseudomonas aeruginosa in the ex vivo infection model. Overall, utilizing fluorous chemistry, we can construct a drug delivery system that exhibits high drug loading capacity, sustained drug release, and robust biological activity.
Original languageEnglish
Pages (from-to)55-64
JournalBiomaterials
Volume124
Early online date31 Jan 2017
DOIs
Publication statusPublished - Apr 2017
Externally publishedYes

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