Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve

Deborah J. Henderson; Lorraine Eley; Jasmin E. Turner; Bill Chaudhry

doi:10.3389/978-2-83250-822-0

Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve

Deborah J. Henderson^*, Lorraine Eley, Jasmin E. Turner, Bill Chaudhry

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapolated from investigations of the atrioventricular valves in animal models, with surprisingly little specifically known about how the arterial valves develop in mouse, and even less in human. In this review, we summarise what is known about the development of the human arterial valve leaflets, comparing this to the mouse where appropriate.

Original language	English
Title of host publication	Vascular and Valvular Tissue Engineering
Subtitle of host publication	Treating and modeling vasculopathies and valvulopathies
Editors	Laura Iop, Adrian Chester, Anthal Smits
Place of Publication	Lausanne, Switzerland
Publisher	Frontiers
Pages	54-64
Number of pages	11
ISBN (Electronic)	9782832508220
DOIs	https://doi.org/10.3389/978-2-83250-822-0
Publication status	Published - Dec 2022
Externally published	Yes

Publication series

Name	Frontiers in Cardiovascular Medicine
Publisher	Frontiers
ISSN (Electronic)	1664-8714

Keywords

arterial valve
semilunar valve
outflow tract cushions
human
development
remodelling
sculpting
bicuspid aortic valve

Access to Document

10.3389/978-2-83250-822-0Licence: CC BY

9782832508220Final published version, 36.1 MBLicence: CC BY

Cite this

Henderson, D. J., Eley, L., Turner, J. E., & Chaudhry, B. (2022). Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve. In L. Iop, A. Chester, & A. Smits (Eds.), Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies (pp. 54-64). (Frontiers in Cardiovascular Medicine). Frontiers. https://doi.org/10.3389/978-2-83250-822-0

Henderson, Deborah J. ; Eley, Lorraine ; Turner, Jasmin E. et al. / Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve. Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies. editor / Laura Iop ; Adrian Chester ; Anthal Smits. Lausanne, Switzerland : Frontiers, 2022. pp. 54-64 (Frontiers in Cardiovascular Medicine).

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abstract = "Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapolated from investigations of the atrioventricular valves in animal models, with surprisingly little specifically known about how the arterial valves develop in mouse, and even less in human. In this review, we summarise what is known about the development of the human arterial valve leaflets, comparing this to the mouse where appropriate.",

keywords = "arterial valve, semilunar valve, outflow tract cushions, human, development, remodelling, sculpting, bicuspid aortic valve",

author = "Henderson, {Deborah J.} and Lorraine Eley and Turner, {Jasmin E.} and Bill Chaudhry",

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Henderson, DJ, Eley, L, Turner, JE & Chaudhry, B 2022, Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve. in L Iop, A Chester & A Smits (eds), Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies. Frontiers in Cardiovascular Medicine, Frontiers, Lausanne, Switzerland, pp. 54-64. https://doi.org/10.3389/978-2-83250-822-0

Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve. / Henderson, Deborah J.; Eley, Lorraine; Turner, Jasmin E. et al.
Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies. ed. / Laura Iop; Adrian Chester; Anthal Smits. Lausanne, Switzerland: Frontiers, 2022. p. 54-64 (Frontiers in Cardiovascular Medicine).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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KW - semilunar valve

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Henderson DJ, Eley L, Turner JE, Chaudhry B. Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve. In Iop L, Chester A, Smits A, editors, Vascular and Valvular Tissue Engineering: Treating and modeling vasculopathies and valvulopathies. Lausanne, Switzerland: Frontiers. 2022. p. 54-64. (Frontiers in Cardiovascular Medicine). doi: 10.3389/978-2-83250-822-0