Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements

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Abstract

A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.
Original languageEnglish
Article number18
Number of pages7
JournalSeparations
Volume6
Issue number1
DOIs
Publication statusPublished - 26 Mar 2019

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