Abstract
A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.
| Original language | English |
|---|---|
| Article number | 18 |
| Number of pages | 7 |
| Journal | Separations |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 26 Mar 2019 |
Keywords
- thyroid
- dissolution
- liquid chromatography-mass spectrometry