DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukaemia

Sabine Langie; Jessica  Timms; Patrick  De Boever; Jill McKay

doi:10.2217/epi-2019-0052

DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukaemia

Sabine Langie, Jessica Timms, Patrick De Boever, Jill McKay

Applied Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

8 Downloads (Pure)

Abstract

Aims: The hygiene hypothesis states lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukaemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to infection. We investigated if aberrant methylation may be in common between these diseases and associated with infection.

Methods: RA and ALL disease-associated methylation signatures were compared and related to exposure-to-infection-signatures.

Results: A significant number of genes overlapped between RA and ALL signatures (p=0.0019). Significant overlaps were observed between exposure-to-infection signatures and disease-associated signatures.

Conclusion: DNA methylation may be a mediating mechanism through which the hygiene hypothesis is associated with RA and ALL risk.

Original language	English
Pages (from-to)	1519-1537
Journal	Epigenomics
Volume	11
Issue number	13
Early online date	19 Sep 2019
DOIs	https://doi.org/10.2217/epi-2019-0052
Publication status	Published - 1 Oct 2019

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title = "DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukaemia",

abstract = "Aims: The hygiene hypothesis states lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukaemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to infection. We investigated if aberrant methylation may be in common between these diseases and associated with infection.Methods: RA and ALL disease-associated methylation signatures were compared and related to exposure-to-infection-signatures.Results: A significant number of genes overlapped between RA and ALL signatures (p=0.0019). Significant overlaps were observed between exposure-to-infection signatures and disease-associated signatures.Conclusion: DNA methylation may be a mediating mechanism through which the hygiene hypothesis is associated with RA and ALL risk.",

keywords = "epigenetics, Allergy, DNA Methylation, childhood acute lymphoblastic leukemia, hygiene hypothesis, infection, exposure, proxy, day care, cold symptoms",

author = "Sabine Langie and Jessica Timms and {De Boever}, Patrick and Jill McKay",

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T1 - DNA methylation and the hygiene hypothesis

T2 - connecting respiratory allergy and childhood acute lymphoblastic leukaemia

AU - Langie, Sabine

AU - Timms, Jessica

AU - De Boever, Patrick

AU - McKay, Jill

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N2 - Aims: The hygiene hypothesis states lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukaemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to infection. We investigated if aberrant methylation may be in common between these diseases and associated with infection.Methods: RA and ALL disease-associated methylation signatures were compared and related to exposure-to-infection-signatures.Results: A significant number of genes overlapped between RA and ALL signatures (p=0.0019). Significant overlaps were observed between exposure-to-infection signatures and disease-associated signatures.Conclusion: DNA methylation may be a mediating mechanism through which the hygiene hypothesis is associated with RA and ALL risk.

AB - Aims: The hygiene hypothesis states lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukaemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to infection. We investigated if aberrant methylation may be in common between these diseases and associated with infection.Methods: RA and ALL disease-associated methylation signatures were compared and related to exposure-to-infection-signatures.Results: A significant number of genes overlapped between RA and ALL signatures (p=0.0019). Significant overlaps were observed between exposure-to-infection signatures and disease-associated signatures.Conclusion: DNA methylation may be a mediating mechanism through which the hygiene hypothesis is associated with RA and ALL risk.

KW - epigenetics

KW - Allergy

KW - DNA Methylation

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KW - hygiene hypothesis

KW - infection

KW - exposure

KW - proxy

KW - day care

KW - cold symptoms

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DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukaemia

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