The accumulated knowledge about corporate entrepreneurship has provided a better understanding of its antecedents and consequences. Corporate entrepreneurship activities are strongly related to incremental or disruptive innovation processes. However, academic debates demand a novel conceptual framework to understand the gendered workforce’s contribution to corporate entrepreneurship initiatives worldwide. This study hypothesizes that a gendered workforce has similar capabilities (skills, ability to detect opportunities, and networks) to engage in corporate entrepreneurship. Therefore, any gender differences could be explained by the influence of country-level conditions (gender equality levels, culture, and social norms). We tested these hypotheses with a sample of 50,550 employees from 50 countries. Our results support these hypotheses extending the corporate entrepreneurship literature and provoking an interesting discussion to academics, managers, employees, and policymakers.