Domain-ligand mapping for enzymes

Matthew Bashton; Janet M Thornton

doi:10.1002/jmr.992

Domain-ligand mapping for enzymes

Matthew Bashton, Janet M Thornton

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

In this paper we provide an overview of our current knowledge of the mapping between small molecule ligands and protein domains. We give an overview of the present data resources available on the Web, which provide information about protein-ligand interactions, as well as discussing our own PROCOGNATE database. We present an update of ligand binding in large protein superfamilies and identify those ligands most frequently utilized by nature. Finally we discuss potential uses for this type of data.

Original language	English
Pages (from-to)	194-208
Number of pages	15
Journal	Journal of Molecular Recognition
Volume	23
Issue number	2
Early online date	6 Oct 2009
DOIs	https://doi.org/10.1002/jmr.992
Publication status	Published - 1 Mar 2010
Externally published	Yes

Keywords

Binding Sites
Databases, Protein
Enzymes/chemistry
Ligands
Molecular Sequence Data
Protein Binding
Protein Structure, Tertiary
Substrate Specificity

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10.1002/jmr.992

Cite this

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title = "Domain-ligand mapping for enzymes",

abstract = "In this paper we provide an overview of our current knowledge of the mapping between small molecule ligands and protein domains. We give an overview of the present data resources available on the Web, which provide information about protein-ligand interactions, as well as discussing our own PROCOGNATE database. We present an update of ligand binding in large protein superfamilies and identify those ligands most frequently utilized by nature. Finally we discuss potential uses for this type of data.",

keywords = "Binding Sites, Databases, Protein, Enzymes/chemistry, Ligands, Molecular Sequence Data, Protein Binding, Protein Structure, Tertiary, Substrate Specificity",

author = "Matthew Bashton and Thornton, {Janet M}",

note = "2009 John Wiley & Sons, Ltd.",

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AU - Bashton, Matthew

AU - Thornton, Janet M

N1 - 2009 John Wiley & Sons, Ltd.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - In this paper we provide an overview of our current knowledge of the mapping between small molecule ligands and protein domains. We give an overview of the present data resources available on the Web, which provide information about protein-ligand interactions, as well as discussing our own PROCOGNATE database. We present an update of ligand binding in large protein superfamilies and identify those ligands most frequently utilized by nature. Finally we discuss potential uses for this type of data.

AB - In this paper we provide an overview of our current knowledge of the mapping between small molecule ligands and protein domains. We give an overview of the present data resources available on the Web, which provide information about protein-ligand interactions, as well as discussing our own PROCOGNATE database. We present an update of ligand binding in large protein superfamilies and identify those ligands most frequently utilized by nature. Finally we discuss potential uses for this type of data.

KW - Binding Sites

KW - Databases, Protein

KW - Enzymes/chemistry

KW - Ligands

KW - Molecular Sequence Data

KW - Protein Binding

KW - Protein Structure, Tertiary

KW - Substrate Specificity

U2 - 10.1002/jmr.992

DO - 10.1002/jmr.992

M3 - Review article

C2 - 19810051

SN - 0952-3499

VL - 23

SP - 194

EP - 208

JO - Journal of Molecular Recognition

JF - Journal of Molecular Recognition

IS - 2

ER -

Domain-ligand mapping for enzymes

Abstract

Keywords

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