Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones

Maurizio Botta, Daniele Castagnolo, Mafalda Pagano, Martina Bernardini

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Abstract

A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields
Original languageEnglish
Pages (from-to)2093-2096
JournalSynlett
Volume2009
Issue number13
DOIs
Publication statusPublished - 2009

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