Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones

Maurizio Botta; Daniele Castagnolo; Mafalda Pagano; Martina Bernardini

doi:10.1055/s-0029-1217700

Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones

Maurizio Botta, Daniele Castagnolo, Mafalda Pagano, Martina Bernardini

Northumbria University

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

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Abstract

A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields

Original language	English
Pages (from-to)	2093-2096
Journal	Synlett
Volume	2009
Issue number	13
DOIs	https://doi.org/10.1055/s-0029-1217700
Publication status	Published - 2009

Keywords

domino reaction
2-aminothiazole
thiazolopyrimidinone
microwave synthesis
antiviral agents

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10.1055/s-0029-1217700

Castagnolo 10985 Synlett 2009 (2)Accepted author manuscript, 312 KB

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abstract = "A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields",

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AU - Botta, Maurizio

AU - Castagnolo, Daniele

AU - Pagano, Mafalda

AU - Bernardini, Martina

PY - 2009

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AB - A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields

KW - domino reaction

KW - 2-aminothiazole

KW - thiazolopyrimidinone

KW - microwave synthesis

KW - antiviral agents

U2 - 10.1055/s-0029-1217700

DO - 10.1055/s-0029-1217700

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Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones

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Keywords

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