Donation after Circulatory Death Lung Activity in the UK – 100 Transplants and Counting

Helen Thomas, Rhiannon Taylor, Andre Simon, Stephen Clark, Joel Dunning, Nizar Yonan, Nicholas Banner, John Dark

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose Whilst the number of donors after brain death (DBD) suitable for lung donation has decreased in the UK over the last ten years, the number of suitable donors after circulatory death (DCD) has increased by 346%. Four of the five adult lung centres in the UK now transplant DCD lungs, with 100 DCD lung transplants now performed. This study aims to examine the differences in donor, recipient and transplant characteristics between the two donor groups and compare the post-transplant outcome. Methods and Materials Data on all adult lung only transplants performed in the UK between January 2002 and October 2012 were obtained from the UK Transplant Registry. Transplant characteristics and outcome were compared using the Wilcoxon, chi-squared or log-rank tests, as appropriate. Results Over the last ten years, 1452 adult lung only transplants were performed in the UK, of which 100 (7%) involved DCD lungs. Over the last three years DCD lung transplants accounted for 14% of activity, which is similar to the DCD activity in Australia and the Netherlands. Where data were available, DCD lung transplants were all performed from controlled DCD, and the majority (87%) were not certified dead by brain stem tests. 84% of DCD lung transplants were bilateral sequential lung transplants (BSLT) compared with 72% of DBD lung transplants (p=0.01). In univariate analysis, DCD transplants also had significantly longer ischaemia times (p
Original languageEnglish
Pages (from-to)S15
JournalThe Journal of Heart and Lung Transplantation
Volume32
Issue numberS4
DOIs
Publication statusPublished - Apr 2013

Fingerprint Dive into the research topics of 'Donation after Circulatory Death Lung Activity in the UK – 100 Transplants and Counting'. Together they form a unique fingerprint.

Cite this