Dormancy Stems the Tide of Chemotherapy

Deepali Pal; Olaf Heidenreich; Josef Vormoor

doi:10.1016/j.ccell.2016.11.014

Dormancy Stems the Tide of Chemotherapy

Deepali Pal, Olaf Heidenreich, Josef Vormoor

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

In this issue of Cancer Cell, Ebinger et al. describe rare, non-cycling blasts in acute lymphoblastic leukemia that combine the phenotypes of dormancy, stemness, and chemo-resistance. This novel in vivo model for dormant blasts will facilitate the dissection of the niche and the development of therapies targeting the leukemic microenvironment.

Original language	English
Pages (from-to)	825-826
Number of pages	2
Journal	Cancer Cell
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2016.11.014
Publication status	Published - 12 Dec 2016
Externally published	Yes

Keywords

Antineoplastic Agents/pharmacology
Drug Resistance, Neoplasm
Humans
Mutation
Neoplastic Stem Cells/drug effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Tumor Microenvironment/drug effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2016.11.014

Cite this

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title = "Dormancy Stems the Tide of Chemotherapy",

abstract = "In this issue of Cancer Cell, Ebinger et al. describe rare, non-cycling blasts in acute lymphoblastic leukemia that combine the phenotypes of dormancy, stemness, and chemo-resistance. This novel in vivo model for dormant blasts will facilitate the dissection of the niche and the development of therapies targeting the leukemic microenvironment.",

keywords = "Antineoplastic Agents/pharmacology, Drug Resistance, Neoplasm, Humans, Mutation, Neoplastic Stem Cells/drug effects, Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Tumor Microenvironment/drug effects",

author = "Deepali Pal and Olaf Heidenreich and Josef Vormoor",

year = "2016",

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doi = "10.1016/j.ccell.2016.11.014",

language = "English",

volume = "30",

pages = "825--826",

journal = "Cancer Cell",

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T1 - Dormancy Stems the Tide of Chemotherapy

AU - Pal, Deepali

AU - Heidenreich, Olaf

AU - Vormoor, Josef

PY - 2016/12/12

Y1 - 2016/12/12

N2 - In this issue of Cancer Cell, Ebinger et al. describe rare, non-cycling blasts in acute lymphoblastic leukemia that combine the phenotypes of dormancy, stemness, and chemo-resistance. This novel in vivo model for dormant blasts will facilitate the dissection of the niche and the development of therapies targeting the leukemic microenvironment.

AB - In this issue of Cancer Cell, Ebinger et al. describe rare, non-cycling blasts in acute lymphoblastic leukemia that combine the phenotypes of dormancy, stemness, and chemo-resistance. This novel in vivo model for dormant blasts will facilitate the dissection of the niche and the development of therapies targeting the leukemic microenvironment.

KW - Antineoplastic Agents/pharmacology

KW - Drug Resistance, Neoplasm

KW - Humans

KW - Mutation

KW - Neoplastic Stem Cells/drug effects

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Tumor Microenvironment/drug effects

U2 - 10.1016/j.ccell.2016.11.014

DO - 10.1016/j.ccell.2016.11.014

M3 - Article

C2 - 27960078

SN - 1535-6108

VL - 30

SP - 825

EP - 826

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

Dormancy Stems the Tide of Chemotherapy

Abstract

Keywords

UN SDGs

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