Liquid-infused surfaces (LISs) exhibit unique properties that make them ideal candidates for a wide range of applications, from antifouling and anti-icing coatings to self-healing surfaces and controlled wetting. However, when exposed to realistic environmental conditions, LISs tend to age and progressively lose their desirable properties, potentially compromising their application. The associated ageing mechanisms are still poorly understood, and results reflecting real-life applications are scarce. Here, we track the ageing of a model LIS composed of glass surfaces functionalized with hydrophobic nanoparticles and infused with silicone oil. The LISs are fully submerged in aqueous solutions and exposed to acoustic pressure waves for set time intervals. The ageing is monitored by periodic measurements of the LIS's wetting properties. We also track the changes to the LIS's nanoscale structure. We find that the LISs rapidly lose their slippery properties because of a combination of oil loss, smoothing of the nanoporous functional layer, and substrate degradation when directly exposed to the solution. The oil loss is consistent with water microdroplets entering the oil layer and displacing oil away from the surface. These mechanisms are general and could play a role in the ageing of most LISs.