Effect of physical activity on the relationship between adiposity and cardiac autonomic modulation in female breast cancer survivors: a longitudinal study

Mariana R. Palma, William R. Tebar, Victor Spiandor Beretta, Luiz Carlos Marques Vanderlei, Cristina E.P.T. Fregonesi, Fernanda E. Ribeiro, Daniela T. Caldeira, Ercy M.C. Ramos, Gabriel G. Cucato, Gerson Ferrari, Raphael Mendes Ritti-Dias, Diego Giulliano Destro Christofaro*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This longitudinal study aimed to analyze the influence of physical activity (PA) on the relationship between body adiposity and cardiac autonomic modulation (CAM) in women survivors of breast cancer. We collected body adiposity through electrical bioimpedance considering body fat percentage (BFP), CAM through heart rate variability (considering RMSSD, SDNN, PNN50, LF (m2), HF (m2), SD1 indexes and SD1/SD2 ratio) and PA through a questionnaire in 64 participants (58.0 ± 9.6 years), recruited through the local association of support for breast cancer and by direct indications from city mastologists. After insertion of PA into the multivariate statistical model, significant attenuation was observed in the relationship between body adiposity and CAM for the indices: SDNN (β = −0.94; 95 percent CI: −1.93; 0.04; p =.060) and SD1/SD2 (β = −0.01;95 percent CI = −0.02; 0.001; p =.065). In conclusion, it was observed that PA was able to mitigate the relationships between BFP and CAM (considering SDNN index and SD1/SD2 ratio) in breast cancer survivors.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalWomen and Health
Volume64
Issue number2
Early online date16 Jan 2024
DOIs
Publication statusPublished - 7 Feb 2024

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