TY - JOUR
T1 - Effect of Sex on Vascular Adaptations to Isometric Handgrip Training in Elderly Patients with Peripheral Artery Disease
T2 - A Randomized Controlled Trial
AU - Oliveira, Paulo
AU - Correia, Marília Almeida
AU - Wolosker, Nelson
AU - Vianna, Lauro C.
AU - Ritti-Dias, Raphael Mendes
AU - Cucato, Gabriel
N1 - Funding Information:
This study was supported by grants from ‘Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP (process# 2016/16425-9), “Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPQ” (process# 310508/2017-7), and “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES.”
Publisher Copyright:
© 2021 S. Karger AG, Basel.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Background: Isometric handgrip training (IHT) promotes vascular adaptations in different populations. Aims: We assessed the sex differences in vascular adaptations of IHT in a sample of older adults with symptomatic peripheral artery disease (PAD). Methods: Fifty-three older patients with symptomatic PAD (6 women and 13 men in IHT and 13 women and 21 men in the control group) participated in this study. The IHT group performed 3 sessions per week, for 8 weeks, consisting of 4 sets of isometric contractions for 2 min at 30% of maximum voluntary contraction and a 4-min interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. Blood flow and brachial flow-mediated dilation were analyzed at before and after 8 weeks of intervention. We compared the responses (Δ= post-pre values) of each group (women control, women IHT, men control, and men IHT) with a Kruskal-Wallis test. Results: There were no differences in all groups after 8 weeks of IHT in Δbrachial diameter (p = 0.850), Δflow-mediated dilation (p = 0.241), Δtime to peak diameter (p = 0.528), and ΔFMD/AUC (p = 0.397). Conclusions: There are no effects of sex on vascular adaptation after 8 weeks of IHT in older adults with symptomatic PAD.
AB - Background: Isometric handgrip training (IHT) promotes vascular adaptations in different populations. Aims: We assessed the sex differences in vascular adaptations of IHT in a sample of older adults with symptomatic peripheral artery disease (PAD). Methods: Fifty-three older patients with symptomatic PAD (6 women and 13 men in IHT and 13 women and 21 men in the control group) participated in this study. The IHT group performed 3 sessions per week, for 8 weeks, consisting of 4 sets of isometric contractions for 2 min at 30% of maximum voluntary contraction and a 4-min interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. Blood flow and brachial flow-mediated dilation were analyzed at before and after 8 weeks of intervention. We compared the responses (Δ= post-pre values) of each group (women control, women IHT, men control, and men IHT) with a Kruskal-Wallis test. Results: There were no differences in all groups after 8 weeks of IHT in Δbrachial diameter (p = 0.850), Δflow-mediated dilation (p = 0.241), Δtime to peak diameter (p = 0.528), and ΔFMD/AUC (p = 0.397). Conclusions: There are no effects of sex on vascular adaptation after 8 weeks of IHT in older adults with symptomatic PAD.
UR - http://www.scopus.com/inward/record.url?scp=85110177340&partnerID=8YFLogxK
U2 - 10.1159/000516499
DO - 10.1159/000516499
M3 - Article
C2 - 34186532
SN - 1018-1172
VL - 58
SP - 388
EP - 391
JO - Journal of Vascular Research
JF - Journal of Vascular Research
IS - 6
ER -