Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication

John Saxton, Irena Zwierska, Kay Hopkinson, E. Espigares, Sohail Choksy, Shah Nawaz, Richard D. Walker, Alan Pockley

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

OBJECTIVES To investigate the effects of exercise training on levels of circulating biomarkers associated with the progression of atherosclerosis and risk of cardiovascular events in patients with intermittent claudication. METHODS Circulating levels of soluble adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), high sensitivity C-reactive protein (hs-CRP) and stress proteins (Hsp60 and Hsp70) in patients randomised to a 24-week programme of arm- or leg-cranking exercise were compared with those in usual care controls. RESULTS Arm and leg exercise similarly improved lower-limb aerobic exercise capacity (20% vs 19%, respectively; P
Original languageEnglish
Pages (from-to)607-13
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume35
Issue number5
DOIs
Publication statusPublished - May 2008

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