Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication

John Saxton; Irena Zwierska; Kay Hopkinson; E. Espigares; Sohail Choksy; Shah Nawaz; Richard D. Walker; Alan Pockley

doi:10.1016/j.ejvs.2007.12.007

Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication

John Saxton, Irena Zwierska, Kay Hopkinson, E. Espigares, Sohail Choksy, Shah Nawaz, Richard D. Walker, Alan Pockley

School of Sport Exercise and Rehabilitation

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

OBJECTIVES To investigate the effects of exercise training on levels of circulating biomarkers associated with the progression of atherosclerosis and risk of cardiovascular events in patients with intermittent claudication. METHODS Circulating levels of soluble adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), high sensitivity C-reactive protein (hs-CRP) and stress proteins (Hsp60 and Hsp70) in patients randomised to a 24-week programme of arm- or leg-cranking exercise were compared with those in usual care controls. RESULTS Arm and leg exercise similarly improved lower-limb aerobic exercise capacity (20% vs 19%, respectively; P

Original language	English
Pages (from-to)	607-13
Journal	European Journal of Vascular and Endovascular Surgery
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.ejvs.2007.12.007
Publication status	Published - May 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

exercise
biomarkers
atherosclerosis

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10.1016/j.ejvs.2007.12.007

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Saxton, J., Zwierska, I., Hopkinson, K., Espigares, E., Choksy, S., Nawaz, S., Walker, R. D., & Pockley, A. (2008). Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. European Journal of Vascular and Endovascular Surgery, 35(5), 607-13. https://doi.org/10.1016/j.ejvs.2007.12.007

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title = "Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication",

abstract = "OBJECTIVES To investigate the effects of exercise training on levels of circulating biomarkers associated with the progression of atherosclerosis and risk of cardiovascular events in patients with intermittent claudication. METHODS Circulating levels of soluble adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), high sensitivity C-reactive protein (hs-CRP) and stress proteins (Hsp60 and Hsp70) in patients randomised to a 24-week programme of arm- or leg-cranking exercise were compared with those in usual care controls. RESULTS Arm and leg exercise similarly improved lower-limb aerobic exercise capacity (20\% vs 19\%, respectively; P",

keywords = "exercise, biomarkers, atherosclerosis",

author = "John Saxton and Irena Zwierska and Kay Hopkinson and E. Espigares and Sohail Choksy and Shah Nawaz and Walker, \{Richard D.\} and Alan Pockley",

note = "Open access article.",

year = "2008",

month = may,

doi = "10.1016/j.ejvs.2007.12.007",

language = "English",

volume = "35",

pages = "607--13",

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Saxton, J, Zwierska, I, Hopkinson, K, Espigares, E, Choksy, S, Nawaz, S, Walker, RD & Pockley, A 2008, 'Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication', European Journal of Vascular and Endovascular Surgery, vol. 35, no. 5, pp. 607-13. https://doi.org/10.1016/j.ejvs.2007.12.007

Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication. / Saxton, John; Zwierska, Irena; Hopkinson, Kay et al.
In: European Journal of Vascular and Endovascular Surgery, Vol. 35, No. 5, 05.2008, p. 607-13.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication

AU - Saxton, John

AU - Zwierska, Irena

AU - Hopkinson, Kay

AU - Espigares, E.

AU - Choksy, Sohail

AU - Nawaz, Shah

AU - Walker, Richard D.

AU - Pockley, Alan

N1 - Open access article.

PY - 2008/5

Y1 - 2008/5

N2 - OBJECTIVES To investigate the effects of exercise training on levels of circulating biomarkers associated with the progression of atherosclerosis and risk of cardiovascular events in patients with intermittent claudication. METHODS Circulating levels of soluble adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), high sensitivity C-reactive protein (hs-CRP) and stress proteins (Hsp60 and Hsp70) in patients randomised to a 24-week programme of arm- or leg-cranking exercise were compared with those in usual care controls. RESULTS Arm and leg exercise similarly improved lower-limb aerobic exercise capacity (20% vs 19%, respectively; P

AB - OBJECTIVES To investigate the effects of exercise training on levels of circulating biomarkers associated with the progression of atherosclerosis and risk of cardiovascular events in patients with intermittent claudication. METHODS Circulating levels of soluble adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), high sensitivity C-reactive protein (hs-CRP) and stress proteins (Hsp60 and Hsp70) in patients randomised to a 24-week programme of arm- or leg-cranking exercise were compared with those in usual care controls. RESULTS Arm and leg exercise similarly improved lower-limb aerobic exercise capacity (20% vs 19%, respectively; P

KW - exercise

KW - biomarkers

KW - atherosclerosis

UR - https://www.scopus.com/pages/publications/41549161127

U2 - 10.1016/j.ejvs.2007.12.007

DO - 10.1016/j.ejvs.2007.12.007

M3 - Article

SN - 1078-5884

VL - 35

SP - 607

EP - 613

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

IS - 5

ER -

Effect of upper- and lower-limb exercise training on circulating soluble adhesion molecules, hs-CRP and stress proteins in patients with intermittent claudication

Abstract

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Keywords

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