Effects of acute vasodilation on the hemodynamic response to muscle metaboreflex

Elisabetta Marongiu, Massimo Piepoli, Raffaele Milia, Luca Angius, Marco Pinna, Pierpaolo Bassareo, Silvana Roberto, Filippo Tocco, Alberto Concu, Antonio Crisafulli

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


The aim of the present study was to test the contribution of stroke volume (SV) in hemodynamic response to muscle metaboreflex activation in healthy individuals. We hypothesized that an acute decrease in cardiac afterload and preload due to the administration of a vasodilating agent could reduce postexercise muscle ischemia (PEMI)-induced SV response. Ten healthy males (age 33.6 ± 1.3 yr) were enrolled and randomly assigned to the following study protocol: 1) PEMI session, 2) control exercise recovery (CER) session, 3) PEMI after sublingual administration of 5 mg of isosorbide dinitrate (ISDN), and 4) CER after ISDN. Central hemodynamics were evaluated by means of impedance cardiography. The main findings were a blunted SV response during metaboreflex following acute arterial and venous vasodilation, associated with a reduction in cardiac diastolic time and filling, and a decrement of systemic vascular resistance. These hemodynamic changes restrain blood pressure response during metaboreflex activation. Our results indicate that hemodynamic response to metaboreflex activation is a highly integrated phenomenon encompassing complex interplay between heart rate, cardiac performance, preload, and afterload and that impairment of one or more of these parameters leads to altered hemodynamic response to metaboreflex.

Original languageEnglish
Pages (from-to)H1387-H1396
Number of pages10
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number9
Early online date30 Aug 2013
Publication statusPublished - 1 Nov 2013
Externally publishedYes


Dive into the research topics of 'Effects of acute vasodilation on the hemodynamic response to muscle metaboreflex'. Together they form a unique fingerprint.

Cite this