TY - JOUR
T1 - Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease
AU - Farah, Breno Quintella
AU - Ritti-Dias, Raphael Mendes
AU - Cucato, Gabriel Grizzo
AU - Chehuen, Marcel da Rocha
AU - Barbosa, João Paulo dos Anjos Souza
AU - Zeratti, Antonio Eduardo
AU - Wolosker, Nelson
AU - Puech-Leao, Pedro
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/2
Y1 - 2014/2
N2 - BACKGROUND: Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.METHODS: This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63 years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.RESULTS: CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR = 3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR = 11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.CONCLUSIONS: CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.
AB - BACKGROUND: Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.METHODS: This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63 years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.RESULTS: CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR = 3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR = 11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.CONCLUSIONS: CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.
KW - Aged
KW - Brazil/epidemiology
KW - Cluster Analysis
KW - Comorbidity
KW - Cross-Sectional Studies
KW - Exercise Test
KW - Exercise Tolerance
KW - Female
KW - Humans
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Peripheral Arterial Disease/diagnosis
KW - Predictive Value of Tests
KW - Risk Factors
KW - Walking
U2 - 10.1016/j.avsg.2013.01.020
DO - 10.1016/j.avsg.2013.01.020
M3 - Article
C2 - 24220650
SN - 0890-5096
VL - 28
SP - 279
EP - 283
JO - Annals of Vascular Surgery
JF - Annals of Vascular Surgery
IS - 2
ER -