Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease

Breno Quintella Farah; Raphael Mendes Ritti-Dias; Gabriel Grizzo Cucato; Marcel da Rocha Chehuen; João Paulo dos Anjos Souza Barbosa; Antonio Eduardo Zeratti; Nelson Wolosker; Pedro Puech-Leao

doi:10.1016/j.avsg.2013.01.020

Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease

Breno Quintella Farah, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato, Marcel da Rocha Chehuen, João Paulo dos Anjos Souza Barbosa, Antonio Eduardo Zeratti, Nelson Wolosker, Pedro Puech-Leao

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.

METHODS: This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63 years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.

RESULTS: CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR = 3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR = 11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.

CONCLUSIONS: CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.

Original language	English
Pages (from-to)	279-283
Number of pages	5
Journal	Annals of Vascular Surgery
Volume	28
Issue number	2
Early online date	9 Nov 2013
DOIs	https://doi.org/10.1016/j.avsg.2013.01.020
Publication status	Published - Feb 2014
Externally published	Yes

Keywords

Aged
Brazil/epidemiology
Cluster Analysis
Comorbidity
Cross-Sectional Studies
Exercise Test
Exercise Tolerance
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Peripheral Arterial Disease/diagnosis
Predictive Value of Tests
Risk Factors
Walking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.avsg.2013.01.020

Cite this

@article{00249f6a383444e8bfa723b52fd8228e,

title = "Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease",

abstract = "BACKGROUND: Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.METHODS: This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63 years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.RESULTS: CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR = 3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR = 11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.CONCLUSIONS: CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.",

keywords = "Aged, Brazil/epidemiology, Cluster Analysis, Comorbidity, Cross-Sectional Studies, Exercise Test, Exercise Tolerance, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Peripheral Arterial Disease/diagnosis, Predictive Value of Tests, Risk Factors, Walking",

author = "Farah, {Breno Quintella} and Ritti-Dias, {Raphael Mendes} and Cucato, {Gabriel Grizzo} and Chehuen, {Marcel da Rocha} and Barbosa, {Jo{\~a}o Paulo dos Anjos Souza} and Zeratti, {Antonio Eduardo} and Nelson Wolosker and Pedro Puech-Leao",

year = "2014",

month = feb,

doi = "10.1016/j.avsg.2013.01.020",

language = "English",

volume = "28",

pages = "279--283",

journal = "Annals of Vascular Surgery",

issn = "0890-5096",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease

AU - Farah, Breno Quintella

AU - Ritti-Dias, Raphael Mendes

AU - Cucato, Gabriel Grizzo

AU - Chehuen, Marcel da Rocha

AU - Barbosa, João Paulo dos Anjos Souza

AU - Zeratti, Antonio Eduardo

AU - Wolosker, Nelson

AU - Puech-Leao, Pedro

PY - 2014/2

Y1 - 2014/2

N2 - BACKGROUND: Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.METHODS: This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63 years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.RESULTS: CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR = 3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR = 11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.CONCLUSIONS: CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.

AB - BACKGROUND: Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.METHODS: This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63 years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.RESULTS: CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR = 3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR = 11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.CONCLUSIONS: CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.

KW - Aged

KW - Brazil/epidemiology

KW - Cluster Analysis

KW - Comorbidity

KW - Cross-Sectional Studies

KW - Exercise Test

KW - Exercise Tolerance

KW - Female

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Peripheral Arterial Disease/diagnosis

KW - Predictive Value of Tests

KW - Risk Factors

KW - Walking

U2 - 10.1016/j.avsg.2013.01.020

DO - 10.1016/j.avsg.2013.01.020

M3 - Article

C2 - 24220650

SN - 0890-5096

VL - 28

SP - 279

EP - 283

JO - Annals of Vascular Surgery

JF - Annals of Vascular Surgery

IS - 2

ER -

Effects of clustered comorbid conditions on walking capacity in patients with peripheral artery disease

Abstract

Keywords

UN SDGs

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