Abstract
Background: The effect of pharmacological and non-pharmacological interventions on physical activity (PA) outcomes across chronic respiratory diseases (CRDs) is not fully elucidated.
Aims and objectives: i) To evaluate the effects of all available interventions on PA outcomes in CRDs; ii) to explore which PA outcomes have been used as endpoints in clinical studies.
Methods: Three different databases were compiled with searches performed in November 2019, July and October 2021, yielding a total of 89 studies.
Results: Compared to usual care (UC), PA behavioural modification interventions, applied alone or alongside exercise training, resulted in significant improvements in the mean (95% CI) steps/day: 1060 (667, 1454) (p<0.00001) and 679 (93, 1266) (p=0.02), respectively. Moreover, bronchodilator therapy in COPD compared to placebo yielded a significant difference in steps/day: 396 (125, 668) (p=0.02). PA behavioural modification interventions compared to UC had a significant effect (p<0.0001) on daily walking time (by 11.84 (5.51, 18.17) min). In patients with CRDs exercise training alone compared to UC led to non-significant (p=0.11) improvements in steps/day (441 (-69, 951)).
Conclusions: Only PA behavioural modification and pharmacological interventions lead to significant improvements compared to the control, in steps/day. The most evaluated PA outcome was steps/day. Clinical and methodological gaps were profound in the literature while large-scale clinical trials are needed to assess the minimal important difference of PA outcomes in response to different pharmacological or non-pharmacological interventions.
Aims and objectives: i) To evaluate the effects of all available interventions on PA outcomes in CRDs; ii) to explore which PA outcomes have been used as endpoints in clinical studies.
Methods: Three different databases were compiled with searches performed in November 2019, July and October 2021, yielding a total of 89 studies.
Results: Compared to usual care (UC), PA behavioural modification interventions, applied alone or alongside exercise training, resulted in significant improvements in the mean (95% CI) steps/day: 1060 (667, 1454) (p<0.00001) and 679 (93, 1266) (p=0.02), respectively. Moreover, bronchodilator therapy in COPD compared to placebo yielded a significant difference in steps/day: 396 (125, 668) (p=0.02). PA behavioural modification interventions compared to UC had a significant effect (p<0.0001) on daily walking time (by 11.84 (5.51, 18.17) min). In patients with CRDs exercise training alone compared to UC led to non-significant (p=0.11) improvements in steps/day (441 (-69, 951)).
Conclusions: Only PA behavioural modification and pharmacological interventions lead to significant improvements compared to the control, in steps/day. The most evaluated PA outcome was steps/day. Clinical and methodological gaps were profound in the literature while large-scale clinical trials are needed to assess the minimal important difference of PA outcomes in response to different pharmacological or non-pharmacological interventions.
| Original language | English |
|---|---|
| Pages (from-to) | 557-557 |
| Number of pages | 1 |
| Journal | European Respiratory Journal |
| Volume | 60 |
| Issue number | suppl 66 |
| DOIs | |
| Publication status | Published - 4 Sept 2022 |
| Event | The European Respiratory Society (ERS) International Congress 2022 - Barcelona, Spain Duration: 4 Sept 2022 → 6 Sept 2022 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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