Efficacy of intracameral and subconjunctival cefuroxime in preventing endophthalmitis after cataract surgery

Patrick Yu-Wai-Man, Stephen Morgan, Anthony Hildreth, David Steel, David Allen

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

Purpose To compare the efficacy of intracameral cefuroxime versus subconjunctival cefuroxime in reducing the rate of endophthalmitis after cataract surgery. Setting Single-specialty eye hospital, Sunderland, United Kingdom. Methods A retrospective analysis of all presumed infectious endophthalmitis cases from January 1, 2000, to December 31, 2006 was performed. The rate of presumed infectious endophthalmitis in patients receiving subconjunctival cefuroxime was compared with those receiving intracameral cefuroxime at the end of surgery. Results This study included 36743 phacoemulsification cataract procedures. The mean rate of presumed infectious endophthalmitis was 0.95 per 1000 cases. The incidence of endophthalmitis was higher in the subconjunctival cefuroxime group than in the intracameral cefuroxime group; the difference was statistically significant with an odds ratio of 3.01 (95% confidence interval, 1.37-6.63). Conclusion Intracameral cefuroxime was a safe alternative to subconjunctival cefuroxime and led to a lower rate of endophthalmitis
Original languageEnglish
Pages (from-to)447-451
JournalJournal of Cataract and Refractive Surgery
Volume34
Issue number3
DOIs
Publication statusPublished - 2008

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