Efficient presentation of endogenous superantigen by H-2A(q)

P. Julian Dyson*, James Elliott, Antony N. Antoniou, Kevin T.T. Corley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Endogenous superantigens encoded by mouse mammary tumor viruses associate with MHC class II and interact with T cells bearing particular Vβ gene segments. H-2E is more efficient at presentation than H-2A, indeed A(q) has not been shown to be capable of presenting endogenous superantigens. Atypically, the superantigen vSAG-3 encoded by Mtv-3 is presented efficiently in non-obese diabetic (H-2(g7)) mice by H-2A; we have examined the independent contributions of VSAG-3 and A(g7) to this process. A(g7) was not found to have a more general ability to efficiently present endogenous superantigens other than Mtv-3. Examination of Mtv-3-mediated thymic deletion of Vβ3+ thymocytes in the presence of H-2(q) additionally demonstrated the efficient presentation of vSAG-3 by A(q). Interaction of vSAG-3 with A(q) and A(g7) is likely to reflect the unique sequence of Mtv-3 within the second polymorphic region previously implicated in MHC class II binding. The demonstration that mouse endogenous superantigens can be presented by a wider range of MHC haplotypes than previously thought is further evidence for their immunological impact on the mouse population.

Original languageEnglish
Pages (from-to)1034-1039
Number of pages6
JournalEuropean Journal of Immunology
Issue number3
Publication statusPublished - 1 Mar 1998
Externally publishedYes


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