TY - JOUR
T1 - Electrocortical Dynamics of Usual Walking and the Planning to Step over Obstacles in Parkinson’s Disease
AU - Vitório, Rodrigo
AU - Lirani-Silva, Ellen
AU - Orcioli-Silva, Diego
AU - Beretta, Victor Spiandor
AU - Oliveira, Anderson Souza
AU - Gobbi, Lilian Teresa Bucken
N1 - Funding information: This research was supported by the Sao Paulo Research Foundation (FAPESP) [2014/22308-0; 2017/19845-1], and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.
PY - 2023/5/18
Y1 - 2023/5/18
N2 - The neural correlates of locomotion impairments observed in people with Parkinson’s disease (PD) are not fully understood. We investigated whether people with PD present distinct brain electrocortical activity during usual walking and the approach phase of obstacle avoidance when compared to healthy individuals. Fifteen people with PD and fourteen older adults walked overground in two conditions: usual walking and obstacle crossing. Scalp electroencephalography (EEG) was recorded using a mobile 64-channel EEG system. Independent components were clustered using a k-means clustering algorithm. Outcome measures included absolute power in several frequency bands and alpha/beta ratio. During the usual walk, people with PD presented a greater alpha/beta ratio in the left sensorimotor cortex than healthy individuals. While approaching obstacles, both groups reduced alpha and beta power in the premotor and right sensorimotor cortices (balance demand) and increased gamma power in the primary visual cortex (visual demand). Only people with PD reduced alpha power and alpha/beta ratio in the left sensorimotor cortex when approaching obstacles. These findings suggest that PD affects the cortical control of usual walking, leading to a greater proportion of low-frequency (alpha) neuronal firing in the sensorimotor cortex. Moreover, the planning for obstacle avoidance changes the electrocortical dynamics associated with increased balance and visual demands. People with PD rely on increased sensorimotor integration to modulate locomotion.
AB - The neural correlates of locomotion impairments observed in people with Parkinson’s disease (PD) are not fully understood. We investigated whether people with PD present distinct brain electrocortical activity during usual walking and the approach phase of obstacle avoidance when compared to healthy individuals. Fifteen people with PD and fourteen older adults walked overground in two conditions: usual walking and obstacle crossing. Scalp electroencephalography (EEG) was recorded using a mobile 64-channel EEG system. Independent components were clustered using a k-means clustering algorithm. Outcome measures included absolute power in several frequency bands and alpha/beta ratio. During the usual walk, people with PD presented a greater alpha/beta ratio in the left sensorimotor cortex than healthy individuals. While approaching obstacles, both groups reduced alpha and beta power in the premotor and right sensorimotor cortices (balance demand) and increased gamma power in the primary visual cortex (visual demand). Only people with PD reduced alpha power and alpha/beta ratio in the left sensorimotor cortex when approaching obstacles. These findings suggest that PD affects the cortical control of usual walking, leading to a greater proportion of low-frequency (alpha) neuronal firing in the sensorimotor cortex. Moreover, the planning for obstacle avoidance changes the electrocortical dynamics associated with increased balance and visual demands. People with PD rely on increased sensorimotor integration to modulate locomotion.
KW - gait
KW - locomotion
KW - movement disorders
KW - EEG
UR - http://www.scopus.com/inward/record.url?scp=85160394791&partnerID=8YFLogxK
U2 - 10.3390/s23104866
DO - 10.3390/s23104866
M3 - Article
SN - 1424-8220
VL - 23
SP - 4866
JO - Sensors
JF - Sensors
IS - 10
M1 - 4866
ER -