Elevation in plasma MMP-9 following carotid endarterectomy is associated with particulate cerebral embolisation

K. J. Molloy; M. M. Thompson; E. C. Schwalbe; P. R.F. Bell; A. R. Naylor; I. M. Loftus

doi:10.1016/j.ejvs.2004.02.001

Elevation in plasma MMP-9 following carotid endarterectomy is associated with particulate cerebral embolisation

K. J. Molloy^*, M. M. Thompson, E. C. Schwalbe, P. R.F. Bell, A. R. Naylor, I. M. Loftus

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Objectives. To study plasma MMP-9 levels before and after carotid endarterectomy (CEA). Design. Observational study.

Methods. Pre-operative (morning of surgery) and post-operative (48 h) plasma samples were obtained from 75 consecutive patients undergoing CEA. MMP-9 concentrations were quantified using ELISA. Transcranial Doppler monitoring was performed on each patient to detect particulate embolisation during the dissection phase of the CEA, until the application of carotid clamps.

Results. The median post-operative plasma MMP-9 level of emboli-positive patients was significantly higher than their median pre-operative value (14.9 ng/ml vs. 8.8 ng/ml; p = 0.038). However, no significant difference was seen in the plasma MMP-9 level of emboli-negative patients (7.7 ng/ml vs. 7.1 ng/ml; p = 0.364). A greater rise was seen in the median plasma MMP-9 levels of those patients suffering > 2 emboli (from 3.4 to 19.3 ng/ml; p = 0.041) than those patients suffering 1 or 2 emboli (from 10.1 to 12.8 ng/ml; p = 0.340).

Conclusions. Plasma MMP-9 only rises after CEA in patients with evidence of embolisation. This increase is more pronounced in those with high numbers of emboli. These data suggest that the increase in MMP-9 is due to cerebral damage caused by embolisation.

Original language	English
Pages (from-to)	409-413
Number of pages	5
Journal	European Journal of Vascular and Endovascular Surgery
Volume	27
Issue number	4
Early online date	18 Feb 2004
DOIs	https://doi.org/10.1016/j.ejvs.2004.02.001
Publication status	Published - 1 Apr 2004
Externally published	Yes

Keywords

Atherosclerosis
Carotid artery plaque
Embolisation
Metalloproteinases
Plasma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejvs.2004.02.001

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@article{8b7dafee169e44b5848f1ba77d4e65c7,

title = "Elevation in plasma MMP-9 following carotid endarterectomy is associated with particulate cerebral embolisation",

abstract = "Objectives. To study plasma MMP-9 levels before and after carotid endarterectomy (CEA). Design. Observational study. Methods. Pre-operative (morning of surgery) and post-operative (48 h) plasma samples were obtained from 75 consecutive patients undergoing CEA. MMP-9 concentrations were quantified using ELISA. Transcranial Doppler monitoring was performed on each patient to detect particulate embolisation during the dissection phase of the CEA, until the application of carotid clamps. Results. The median post-operative plasma MMP-9 level of emboli-positive patients was significantly higher than their median pre-operative value (14.9 ng/ml vs. 8.8 ng/ml; p = 0.038). However, no significant difference was seen in the plasma MMP-9 level of emboli-negative patients (7.7 ng/ml vs. 7.1 ng/ml; p = 0.364). A greater rise was seen in the median plasma MMP-9 levels of those patients suffering > 2 emboli (from 3.4 to 19.3 ng/ml; p = 0.041) than those patients suffering 1 or 2 emboli (from 10.1 to 12.8 ng/ml; p = 0.340). Conclusions. Plasma MMP-9 only rises after CEA in patients with evidence of embolisation. This increase is more pronounced in those with high numbers of emboli. These data suggest that the increase in MMP-9 is due to cerebral damage caused by embolisation.",

keywords = "Atherosclerosis, Carotid artery plaque, Embolisation, Metalloproteinases, Plasma",

author = "Molloy, {K. J.} and Thompson, {M. M.} and Schwalbe, {E. C.} and Bell, {P. R.F.} and Naylor, {A. R.} and Loftus, {I. M.}",

note = "Funding Information: The project was funded by The UK Stroke Association.",

year = "2004",

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day = "1",

doi = "10.1016/j.ejvs.2004.02.001",

language = "English",

volume = "27",

pages = "409--413",

journal = "European Journal of Vascular and Endovascular Surgery",

issn = "1078-5884",

publisher = "W.B. Saunders",

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TY - JOUR

T1 - Elevation in plasma MMP-9 following carotid endarterectomy is associated with particulate cerebral embolisation

AU - Molloy, K. J.

AU - Thompson, M. M.

AU - Schwalbe, E. C.

AU - Bell, P. R.F.

AU - Naylor, A. R.

AU - Loftus, I. M.

N1 - Funding Information: The project was funded by The UK Stroke Association.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - Objectives. To study plasma MMP-9 levels before and after carotid endarterectomy (CEA). Design. Observational study. Methods. Pre-operative (morning of surgery) and post-operative (48 h) plasma samples were obtained from 75 consecutive patients undergoing CEA. MMP-9 concentrations were quantified using ELISA. Transcranial Doppler monitoring was performed on each patient to detect particulate embolisation during the dissection phase of the CEA, until the application of carotid clamps. Results. The median post-operative plasma MMP-9 level of emboli-positive patients was significantly higher than their median pre-operative value (14.9 ng/ml vs. 8.8 ng/ml; p = 0.038). However, no significant difference was seen in the plasma MMP-9 level of emboli-negative patients (7.7 ng/ml vs. 7.1 ng/ml; p = 0.364). A greater rise was seen in the median plasma MMP-9 levels of those patients suffering > 2 emboli (from 3.4 to 19.3 ng/ml; p = 0.041) than those patients suffering 1 or 2 emboli (from 10.1 to 12.8 ng/ml; p = 0.340). Conclusions. Plasma MMP-9 only rises after CEA in patients with evidence of embolisation. This increase is more pronounced in those with high numbers of emboli. These data suggest that the increase in MMP-9 is due to cerebral damage caused by embolisation.

AB - Objectives. To study plasma MMP-9 levels before and after carotid endarterectomy (CEA). Design. Observational study. Methods. Pre-operative (morning of surgery) and post-operative (48 h) plasma samples were obtained from 75 consecutive patients undergoing CEA. MMP-9 concentrations were quantified using ELISA. Transcranial Doppler monitoring was performed on each patient to detect particulate embolisation during the dissection phase of the CEA, until the application of carotid clamps. Results. The median post-operative plasma MMP-9 level of emboli-positive patients was significantly higher than their median pre-operative value (14.9 ng/ml vs. 8.8 ng/ml; p = 0.038). However, no significant difference was seen in the plasma MMP-9 level of emboli-negative patients (7.7 ng/ml vs. 7.1 ng/ml; p = 0.364). A greater rise was seen in the median plasma MMP-9 levels of those patients suffering > 2 emboli (from 3.4 to 19.3 ng/ml; p = 0.041) than those patients suffering 1 or 2 emboli (from 10.1 to 12.8 ng/ml; p = 0.340). Conclusions. Plasma MMP-9 only rises after CEA in patients with evidence of embolisation. This increase is more pronounced in those with high numbers of emboli. These data suggest that the increase in MMP-9 is due to cerebral damage caused by embolisation.

KW - Atherosclerosis

KW - Carotid artery plaque

KW - Embolisation

KW - Metalloproteinases

KW - Plasma

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DO - 10.1016/j.ejvs.2004.02.001

M3 - Article

C2 - 15015192

AN - SCOPUS:1642391443

SN - 1078-5884

VL - 27

SP - 409

EP - 413

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

IS - 4

ER -

Elevation in plasma MMP-9 following carotid endarterectomy is associated with particulate cerebral embolisation

Abstract

Keywords

UN SDGs

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