Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

Ellen Graf, Kathrin Schneider, Graeme Nicholson, Markus Ströbele, Amanda Jones, Michael Goodfellow, Winfried Beil, Roderich Süssmuth, Hans-Peter Fiedler

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
Original languageEnglish
Pages (from-to)277-284
JournalJournal of Antibiotics
Volume60
DOIs
Publication statusPublished - 2007

Fingerprint

Dive into the research topics of 'Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871'. Together they form a unique fingerprint.

Cite this