Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

Ellen Graf; Kathrin Schneider; Graeme Nicholson; Markus Ströbele; Amanda Jones; Michael Goodfellow; Winfried Beil; Roderich Süssmuth; Hans-Peter Fiedler

doi:10.1038/ja.2007.35

Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

Ellen Graf, Kathrin Schneider, Graeme Nicholson, Markus Ströbele, Amanda Jones, Michael Goodfellow, Winfried Beil, Roderich Süssmuth, Hans-Peter Fiedler

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

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Abstract

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

Original language	English
Pages (from-to)	277-284
Journal	Journal of Antibiotics
Volume	60
DOIs	https://doi.org/10.1038/ja.2007.35
Publication status	Published - 2007

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abstract = "Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.",

author = "Ellen Graf and Kathrin Schneider and Graeme Nicholson and Markus Str{\"o}bele and Amanda Jones and Michael Goodfellow and Winfried Beil and Roderich S{\"u}ssmuth and Hans-Peter Fiedler",

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AU - Graf, Ellen

AU - Schneider, Kathrin

AU - Nicholson, Graeme

AU - Ströbele, Markus

AU - Jones, Amanda

AU - Goodfellow, Michael

AU - Beil, Winfried

AU - Süssmuth, Roderich

AU - Fiedler, Hans-Peter

PY - 2007

Y1 - 2007

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AB - Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

U2 - 10.1038/ja.2007.35

DO - 10.1038/ja.2007.35

M3 - Article

SN - 0021-8820

VL - 60

SP - 277

EP - 284

JO - Journal of Antibiotics

JF - Journal of Antibiotics

ER -

Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

Abstract

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