Elucidating the unexplained underperformance syndrome in endurance athletes: the Interleukin-6 hypothesis

Paula Robson-Ansley

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

The unexplained underperformance syndrome (UPS), previously known as the overtraining syndrome (OTS), has been defined as a persistent decrement in athletic performance capacity despite 2 weeks of relative rest. It has been proposed that UPS may be caused by excessive cytokine release during and following exercise causing a chronic inflammatory state and 'cytokine sickness'. This article extends that hypothesis by proposing that time-dependent sensitisation could provide a model through which the aetiology of UPS may be explained. In this model, the principal abnormal factors in UPS are an increased production of and/or intolerance to interleukin (IL)-6 during exercise. Strategies to attenuate the IL-6 response to exercise that may also reduce an athlete's susceptibility to UPS are proposed.
Original languageEnglish
Pages (from-to)771-781
JournalSports Medicine
Volume33
Issue number10
DOIs
Publication statusPublished - Jan 2003

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