Enantioselective detection of l-serine

Simon Stanley, Carl Percival, T. Morel, Alan Braithwaite, Michael Newton, Glen McHale, Wayne Hayes

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively detect the amino acid L-serine. A highly specific non-covalently imprinted polymer was cast on one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the L-serine was observed as a frequency shift in the QCM with a detection limit of 2 ppb and for concentrations up to 0.4 ppm. The sensor binding is shown to be capable of discrimination between L- and D-stereoisomers of serine as a result of the enantioselectivity of the imprinted binding sites.
Original languageEnglish
Pages (from-to)103-106
JournalSensors and Actuators B: Chemical
Volume89
Issue number1-2
DOIs
Publication statusPublished - 1 Mar 2003

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