Enantioselective detection of l-serine

Simon Stanley; Carl Percival; T. Morel; Alan Braithwaite; Michael Newton; Glen McHale; Wayne Hayes

doi:10.1016/S0925-4005(02)00449-5

Enantioselective detection of l-serine

Simon Stanley, Carl Percival, T. Morel, Alan Braithwaite, Michael Newton, Glen McHale, Wayne Hayes

SE Faculty Management and Administration

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively detect the amino acid L-serine. A highly specific non-covalently imprinted polymer was cast on one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the L-serine was observed as a frequency shift in the QCM with a detection limit of 2 ppb and for concentrations up to 0.4 ppm. The sensor binding is shown to be capable of discrimination between L- and D-stereoisomers of serine as a result of the enantioselectivity of the imprinted binding sites.

Original language	English
Pages (from-to)	103-106
Journal	Sensors and Actuators B: Chemical
Volume	89
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4005(02)00449-5
Publication status	Published - 1 Mar 2003

Keywords

molecular imprinted polymers (MIPs)
quartz crystal microbalance (QCM)
sensor

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10.1016/S0925-4005(02)00449-5

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title = "Enantioselective detection of l-serine",

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AU - Stanley, Simon

AU - Percival, Carl

AU - Morel, T.

AU - Braithwaite, Alan

AU - Newton, Michael

AU - McHale, Glen

AU - Hayes, Wayne

PY - 2003/3/1

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AB - An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively detect the amino acid L-serine. A highly specific non-covalently imprinted polymer was cast on one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the L-serine was observed as a frequency shift in the QCM with a detection limit of 2 ppb and for concentrations up to 0.4 ppm. The sensor binding is shown to be capable of discrimination between L- and D-stereoisomers of serine as a result of the enantioselectivity of the imprinted binding sites.

KW - molecular imprinted polymers (MIPs)

KW - quartz crystal microbalance (QCM)

KW - sensor

UR - https://www.scopus.com/pages/publications/0037366315

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DO - 10.1016/S0925-4005(02)00449-5

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EP - 106

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

IS - 1-2

ER -

Enantioselective detection of l-serine

Abstract

Keywords

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